- Ashcroft Group Research Group
DBE, FRS, FMedSci
GlaxoSmithKline Royal Society Professor
Frances Ashcroft is the Royal Society GlaxoSmithKline Research Professor at the University Laboratory of Physiology, Oxford and a Fellow of Trinity College, Oxford. She holds BA, PhD and ScD degrees from Cambridge University and was elected a Fellow of the Royal Society of London in 1999. Her research focuses on ATP-sensitive potassium (KATP) channels and their role in insulin secretion, in both health and disease. She is interested in how KATP channel function relates to channel structure, how cell metabolism regulates channel activity, and how mutations in KATP channel genes cause human disease. The ultimate goal is to elucidate how a rise in the blood glucose concentration stimulates the release of insulin from the pancreatic beta-cells, what goes wrong with this process in type 2 diabetes, and how drugs used to treat this condition exert their beneficial effects. She has written a text book Ion Channels and Disease and is Director of OXION, a training and research programme on the integrative physiology of ion channels, funded by the Wellcome Trust.
Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes.
Babiker T. et al, (2016), Diabetologia, 59, 1162 - 1166
Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.
Zhang Q. et al, (2014), J Physiol, 592, 4677 - 4696
Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells.
Tornovsky-Babeay S. et al, (2014), Cell Metab, 19, 109 - 121
Control of pancreatic β cell regeneration by glucose metabolism.
Porat S. et al, (2011), Cell Metab, 13, 440 - 449
Overexpression of Fto leads to increased food intake and results in obesity.
Church C. et al, (2010), Nat Genet, 42, 1086 - 1092