Contact information
| kc.park@queens.ox.ac.uk | |
| Tel | +44 (0)1865 282160 |
My Connections
-
The Queen's College
College
- BHF CRE Oxford British Heart Foundation Centre of Research Excellence
- BSCR British Society for Cardiovascular Research
- Smart Group Research Group
- Swietach Group Research Group
Voltage-Clamping Ventricular Myocytes
Kyung Chan (Kc) Park
BSc (Hons)
British Heart Foundation DPhil Student
Focus: Cellular physiology of the cardiac myocyte
My longstanding interest in the biology of the heart led me to focus on a range of topics pertaining to cardiovascular science during my undergraduate degree (Biomedical Sciences, King’s College London). Under the supervision of Professor Michael Marber, my dissertation considered cardiac troponin as a commonly used biomarker, but an imperfect, index of myocardial injury.
After graduating in 2015, I subsequently joined the laboratory of Professor Michael Shattock at the Rayne Institute (BHF Centre of Research Excellence, King’s College London) on a Physiological Society Studentship, primarily to identify stimulators of the cardiac Na/K ATPase. During the studentship, I also assessed the cardioprotective effects of thrombopoietin against ischaemia/reperfusion injury (Dr Michael Curtis) and studied the role of action potential restitution on arrhythmogenesis (Dr James Winter; see Coronel R. Cardiovasc Res 2017;113:705-707).
In 2016, I commenced the British Heart Foundation 4-Year Non-Clinical PhD Studentship at the University of Oxford as a Postgraduate Student of The Queen’s College. After a rotation project with Associate Professor Craig Lygate (Cardiac Energetics Group), I joined the Department in 2017 as a DPhil student of Associate Professor Pawel Swietach. The Group’s research focusses on the role of pH and calcium on the physiology of the heart and cancer. In keeping with these interests, under co-supervision from Dr Nicola Smart, my doctoral research will investigate the effects of metabolic acidoses associated with inborn errors of metabolism on cardiac physiology. In particular, I will explore the effects of propionic acid and its derivatives on the heart at the molecular, cellular, and organ-level. By combining techniques in electrophysiology, bioinformatics, imaging, and molecular biology, I hope to gain a greater understanding of how pH affects cardiac physiology in health and disease.
Key experimental approaches
Patch-Clamping
Langendorff Heart Perfusion
Key Publications
5-
Cardiac Troponins: From Myocardial Infarction To Chronic Disease
Park KC. et al, Cardiovascular Research
-
Restitution slope is principally determined by steady-state action potential duration
Shattock MJ. et al, (2017), Cardiovascular Research, 113, 817 - 828
Recent Publications
5-
Restitution slope is principally determined by steady-state action potential duration
Shattock MJ. et al, (2017), Cardiovascular Research, 113, 817 - 828
-
Coagulation Screens Requested In An Emergency Department: Clinically Indicated Or Not?
Park K. et al, (2014), Emergency Medicine Journal, 31, 791.2 - 791
-
Endoscopic transsphenoidal drainage of an aggressive petrous apex cholesterol granuloma: unusual complications and lessons learnt
Park KC. et al, (2013), The Journal of Laryngology & Otology, 127, 1230 - 1234
-
Phospholemman
Park KC. et al, Encyclopedia of Signaling Molecules
-
Cardiac Troponins: From Myocardial Infarction To Chronic Disease
Park KC. et al, Cardiovascular Research