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Found 328 matches for

Welcome to OXION, Universities of Oxford, Cambridge, London and MRC Harwell

Understanding the role of little known gene in regulating our metabolism

Thousands of genes are involved in the regulation of our day-to-day metabolism and relatively little is understood about their function. One key protein, an ABC Transporter called ABCC5, has recently been predicted to be a susceptibility gene for Type 2 diabetes. In a new study selected as Editor's Choice in Obesity, Associate Professor Heidi de Wet has confirmed ABCC5's role in energy metabolism and identified the mechanism behind its metabolic impact for the first time.

Potential strategy identified to improve blood vessel growth after heart attack

A collaborative paper from the De Val and Smart Groups has established multiple regulatory pathways responsible for the formation of blood vessels in the developing heart. In doing so they have identified a crucial pathway that is repressed in the adult heart after injury, which may hold the key to a new and improved strategy for repair.

New study discovers the impact of environment on sleep patterns in wild primates

Associate Professor Vladyslav Vyazovskiy has co-authored a paper based on a pioneering sleep study led by Oxford Brookes researchers. Their research into a nocturnal primate performed in the wild is the first of its kind and could enhance our understanding of human sleep.

New approach to reducing damage after a heart attack

During the emergency procedure used to reopen the blocked artery causing a heart attack, smaller "micro" blood vessels can remain constricted causing significant damage. A new study led by Associate Professor Neil Herring and published in the European Heart Journal has established a key cause behind this constriction and identified a potential therapeutic target to block the mechanism behind it.

Sarah De Val set to expand critical research into endothelial cell dysfunction in cardiovascular disease

Prof Sarah De Val in collaboration with Dr Gillian Douglas from the Radcliffe Department of Medicine has received a grant from the John Fell Fund to support their work investigating the behaviour of different endothelial regulatory pathways during disorders of the cardiovascular system.

Critical role demonstrated for the auditory cortex in adapting to hearing loss

A collaborative King Group study published today in Nature Communications enhances our understanding of how our brains learn to adapt to abnormal sensory changes such as hearing loss. Their results could inform the future development of devices that restore hearing or other sensory impairments.

Cardiac, metabolism and cell physiology researchers come together for Integrative Physiology Theme Day

The Department's third and final theme day of the year culminated in a series of exciting internal talks from a diverse range of research groups covering all aspects of integrative physiology. From diabetes to iron deficiency, from pH physiology to cancer cells, the talks showcased the huge breadth of science studied across DPAG.

Kieran Clarke answers the Big Question: Why are athletes using ketones?

Ketones are billed as the alternative energy source in the athletic world. With Tour de France 2019 just round the corner, this week Professor Kieran Clarke features on the Oxford Sparks Big Questions podcast to answer the question: why are professional cyclists using ketones?

BHF Senior Fellowship renewal for Nicola Smart paves the way for stimulating vessel growth to repair damaged hearts

Congratulations are in order for Associate Professor Nicola Smart, who has been awarded a renewal of her British Heart Foundation Senior Basic Science Research Fellowship. The award will fund research investigating the processes behind blood vessel growth in order to understand how to stimulate heart repair after injury.

Drinking alcohol at conception shown to cause harm

Research carried out by Postdoctoral Research Scientist Jacinta Kalisch-Smith during her PhD, now published in Development, reveals key insights into the effects of alcohol in the very early stages of pregnancy, a stage during which a mother is unlikely to know she is pregnant.

Key insights into the underlying mechanisms behind Type 2 diabetes

Research led by Postdoctoral Research Scientist Dr Elizabeth Haythorne and published in Nature Communications sheds light on a vicious cycle that causes specialised cells to fail in their function to maintain healthy bloody sugar levels.

Development and Cell Biology Researchers showcased in diverse and collaborative annual event

A series of internal talks demonstrated an extensive breadth of research within the Development and Cell Biology Theme that tackles the questions fundamental to understanding evolution, growth, organ formation, the onset of disease and tissue regeneration. DPAG Researchers were also joined by two external speakers presenting their research into age-related angiocrine signals and stem cell strategies for lung development.

Postdoctoral researchers and students shine at Neuroscience Theme Day

The talks given by Postdoctoral Research Scientists and Graduate Students highlighted the full range of research in DPAG, spanning molecular and cellular neuroscience all the way to systems neuroscience.

Critical link revealed between iron deficiency and a serious cardiovascular condition

A new discovery from the Lakhal-Littleton Group on how iron deficiency affects the vasculature of the lung could hold the key to improving treatment of pulmonary arterial hypertension.

New research advances our understanding of vascular development

Dr Oliver Stone’s paper “Paraxial mesoderm is the major source of lymphatic endothelium” published in Developmental Cell reveals the earliest known step in the formation of the lymphatic vasculature.

DPAG postdocs enjoy success at Interdepartmental Postdoctoral Poster Session

Rhys Evans co-authors bestselling guide to human metabolism and metabolic regulation

The revised and updated "Human Metabolism: A Regulatory Perspective" offers a new and integrated review of metabolism and metabolic regulation, where difficult concepts are explained in clear and concise terms to provide an accessible and essential guide to the topic.

BHF Intermediate Basic Science Research Fellowship awarded to Joaquim Miguel Vieira to promote the investigation of non-coding transcripts in heart development and disease

Congratulations are in order for Senior Postdoctoral Research Scientist Dr Joaquim Miguel Vieira, who was been awarded an Intermediate Fellowship from the British Heart Foundation. This award will fund research designed to better understand the basic mechanisms behind cardiovascular development and could pave the way for innovative treatments of heart disease.

New way to target and treat the leading genetic contributor to Parkinson's

The Wade-Martins Group has identified how the dysfunction of a key protein, LRRK2, causes the neurons affected in Parkinson's to lose their ability to effectively clear out cell components that have been damaged. This discovery has enabled the team to find a new way to target and correct this issue, paving the way for a potential new clinical treatment.

Adam Packer discusses how sculpted light in the brain helps us to better understand brain function ahead of innovative annual conference

In a new interview with Scientifica, Dr Adam Packer reveals plans for the 2019 Sculpted Light in the Brain conference, to be held at the Royal Society in June.

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