Department of Physiology, Anatomy and Genetics (DPAG)

Fellowship to Jose Prius Mengual paves the way to new genetic therapy for epilepsy

22 May 2023

Congratulations are in order to Dr Jose Prius Mengual who has been awarded an Emerging Leader Fellowship Award from Epilepsy Research UK and the Nucleic Acid Therapy Accelerator (NATA). With this award, Dr Mengual will develop a new genetic therapy to rebalance protein levels in the neurons affected by epilepsy to prevent seizures.

Can humans hibernate?

20 March 2023

Illuminating new TEDx Talk from Professor of Sleep Physiology Vladyslav Vyazovskiy

New insights into chemogenetic designer drugs to enhance our study of behaviour

10 March 2023

A collaborative team of researchers in DPAG and Pharmacology led by Dr Lukas Krone have uncovered striking new data demonstrating that two widely used designer drugs used to turn populations of neurons on and off in the brain cause unexpected effects on sleep. These results demonstrate a critical need to improve chemogenetic approaches in behavioural studies.

New BBSRC grant to further our insights into how the cortex controls sleep

15 December 2022

Professor of Sleep Physiology Vladyslav Vyazovskiy and Professor of Developmental Neuroscience Zoltán Molnár have been awarded a Project Grant from the Biotechnology and Biological Sciences Research Council (BBSRC) for “Brain mechanisms of sleep: top-down or bottom-up?”

Raised intracellular chloride levels underlie the effects of tiredness in cortex

13 December 2022

A new study, co-authored by Professor Vladyslav Vyazovskiy, published in Nature Neuroscience, has revealed that intracellular chloride levels within cortical pyramidal neurons reflect sleep–wake history.

Vladyslav Vyazovskiy reflects on the Braemar Summit 2022

1 November 2022

Professor of Sleep Physiology Vladyslav Vyazovskiy was invited to attend the Braemar Summit 2022, a prestigious annual conference attended by around 100 participants, showcasing the best that is being said and thought in the UK.

Vladyslav Vyazovskiy elected Vice President of the European Sleep Research Society

3 October 2022

Congratulations are in order to Professor Vladyslav Vyazovskiy on his appointment as Vice President (Basic) of the European Sleep Research Society (ESRS).

Little understood brain region linked to how we perceive pain

28 March 2022

A new DPAG-led review paper, published in the journal Brain, has shown that a poorly understood region of the brain called the claustrum may play an important role in how we experience pain.

Switch with a spring: a new model for sleep regulation

16 December 2021

New collaborative research led by the Vyazovskiy Group has shed new light on the role of the hypothalamus in the transition between sleep and wake states.

Vladyslav Vyazovskiy becomes Professor Vladyslav Vyazovskiy

9 December 2021

Congratulations are in order to Vladyslav Vyazovskiy on his conferral of the title of full Professor. Research in the Vyazovskiy Lab aims to understand the fundamental questions of "what is sleep?" and “why do we sleep?”

Feeling tired? Here’s how the brain’s ‘hourglass’ controls your need for sleep – new research

24 August 2021

New article on The Conversation website written by Dr Lukas Krone, Associate Professor Vladyslav Vyazovskiy and Professor Zoltán Molnár.

Gosia Cyranka and Sian Wilcox honoured by The Physiological Society

6 August 2021

DPAG DPhil students Gosia Cyranka and Sian Wilcox have been awarded prestigious Early Career Researcher Prizes at Physiology 2021, The Physiological Society's Annual Conference celebrating first-class physiology.

Continued ethical animal research needed to advance treatment of brain disease, researchers argue

5 August 2021

More research is needed to improve the treatment of brain diseases such as depression, Alzheimer’s or ADHD. A widely held view within the scientific community is that this cannot be done without ethically conducted animal research. A team of seventy international neuroscientists, including DPAG’s Associate Professor Vladyslav Vyazovskiy, have now published a warning that animal research is under pressure, which endangers the further development of treatments.

Cortex may regulate the need for sleep

2 August 2021

Why we sleep, and the processes behind sleep, are amongst the most interesting questions in modern neuroscience. Researchers at the University of Oxford, including DPAG's Molnár and Vyazovskiy group scientists, have now uncovered a new target for sleep investigations within the mammalian brain – the cerebral cortex. The paper, first authored by Dr Lukas Krone, was published today in Nature Neuroscience.

Being "in the zone": how waking activity controls sleep need

7 April 2021

A new study from the Vyazovskiy group suggests that how and where we spend our time while awake impacts how much we need to sleep - it does not only depend on how long we are awake.

Lukas Krone to represent Oxford at the Global Young Scientists Summit

3 December 2020

Congratulations are in order for Dr Lukas Krone who is one of just five University of Oxford researchers selected to attend the Global Young Scientists Summit 2021.

Lukas Krone honoured by the World Sleep Society

16 October 2020

Congratulations are in order for Lukas Krone, who has been presented the 2020 Christian Guilleminault Young Investigator Award by the World Sleep Society.

How brain networks cooperate to control our sleep

13 August 2020

Two new papers from the Vyazovskiy Group and both Oxford University and international collaborators have made important progress in bridging the gap between the local and global levels of sleep regulation.

Shaping our understanding of why we sleep

1 July 2020

Associate Professor Vladyslav Vyazovskiy has edited a special issue of Current Opinion of Physiology with Professor A. Jennifer Morton from the University of Cambridge. “Physiology of Sleep” compiles the latest developments in sleep research around the complex question of ‘why do we sleep?’

Cristina Blanco Duque is a CSF 2019 Award Winner

7 November 2019

Congratulations are in order for Wellcome Trust doctoral student Cristina Blanco Duque, the winner of the Travel Award and the Award for Best Contribution at the International Conference of Advanced Sleep Modulation Technologies.

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