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Oxford-led research maps milestone stage of human development for the first time
Postdoctoral Publication Research Srinivas Group news
18 November 2021
Scientists have shed light on an important stage of early embryonic development that has never been fully mapped out in humans before.
Drug could help diabetic hearts recover after a heart attack
Cardiac Theme Heather Group News Publication Research
20 October 2021
New research led by Associate Professor Lisa Heather has found that a drug known as molidustat, currently in clinical trials for another condition, could reduce risk of heart failure after heart attacks.
Blood bank storage can reduce ability of transfusions to treat anaemia
Cell Physiology Publication Research
13 September 2021
New research from the Swietach Group in collaboration with NHS Blood and Transplant has demonstrated that the process of storing blood in blood banks can negatively impact the function of red blood cells and consequently may reduce the effectiveness of blood transfusions, a treatment commonly used to combat anaemia.
Overlapping second messengers increase dynamic control of physiological responses
Cell Physiology Publication Research
3 September 2021
New research from the Parekh and Zaccolo groups reveals that a prototypical anchoring protein, known to be responsible for regulating several important physiological processes, also orchestrates the formation of two important universal second messengers.
Feeling tired? Here’s how the brain’s ‘hourglass’ controls your need for sleep – new research
Publication Research Vyazovskiy Group News
24 August 2021
New article on The Conversation website written by Dr Lukas Krone, Associate Professor Vladyslav Vyazovskiy and Professor Zoltán Molnár.
Scientists Decipher How NeuroImmune Interactions Burn Deep Fat
Domingos Group News Publication Research
20 August 2021
A pioneering collaborative mouse study from an international team of researchers including DPAG's Associate Professor Ana Domingos published in Nature offers new therapeutic avenues for reducing visceral fat stores, which have been associated with cardiovascular disease and multiple types of cancer.
Continued ethical animal research needed to advance treatment of brain disease, researchers argue
Publication Research Vyazovskiy Group News
5 August 2021
More research is needed to improve the treatment of brain diseases such as depression, Alzheimer’s or ADHD. A widely held view within the scientific community is that this cannot be done without ethically conducted animal research. A team of seventy international neuroscientists, including DPAG’s Associate Professor Vladyslav Vyazovskiy, have now published a warning that animal research is under pressure, which endangers the further development of treatments.
Cortex may regulate the need for sleep
Integrative Neuroscience Molnar Group News Publication Research Vyazovskiy Group News
2 August 2021
Why we sleep, and the processes behind sleep, are amongst the most interesting questions in modern neuroscience. Researchers at the University of Oxford, including DPAG's Molnár and Vyazovskiy group scientists, have now uncovered a new target for sleep investigations within the mammalian brain – the cerebral cortex. The paper, first authored by Dr Lukas Krone, was published today in Nature Neuroscience.
Reducing fat in the diabetic heart could improve recovery from heart attack
Heather Group News Publication Research
29 July 2021
New research from the Heather Group has shown that in type 2 diabetes an overload of lipids reduces the heart’s ability to generate energy during a heart attack, decreasing chances of recovery.
The brain’s one-sided teaching signals
Integrative Neuroscience Publication Research
16 July 2021
A new study by the Lak group reveals a novel facet of dopamine signalling during visual decision making.
The future of stroke treatment
Publication Research Salman Group News Wade-Martins Group News
5 July 2021
A team of international collaborators including DPAG's Dr Mootaz Salman has been researching a promising new therapeutic for the treatment of strokes and other brain injuries.
New review reveals proof of concept for an anti-obesity immunotherapy
Domingos Group News Publication Research
2 July 2021
The Domingos lab has published a new opinion piece in Science investigating the implications of a Memorial Sloan Kettering Cancer Center study that lays the foundations for a potential new anti-obesity treatment in the form of targeting adipose tissue-resident macrophages.
New pathway established for multisensory cortical communication
Integrative Neuroscience Publication Research
28 June 2021
Integration of information across the senses is critical for perception. This activity is thought to arise primarily from connections made in the brain's sensory cortical areas. A new paper from the King Group uncovers evidence for the first time on the little understood role of subcortical circuits in shaping the multisensory properties of primary cortical neurons.
Iron deficiency anaemia in early pregnancy increases risk of heart defects, suggests new research
Cardiac Theme Postdoctoral Publication Research
8 June 2021
In animal models, iron deficient mothers have a greatly increased risk of having offspring with congenital heart disease (CHD). The risk of CHD can be greatly reduced if the mother is given iron supplements very early in pregnancy. Additionally, embryos from a mouse model of Down Syndrome were particularly vulnerable to the effects of maternal iron deficiency, leading to a higher risk of developing severe heart defects.
New target to develop immunosuppressants
Cell Physiology Publication Research
18 May 2021
A new study from the Parekh Group has resolved a long-standing question in our understanding of intracellular Ca2+ signalling, namely how a specific type of Ca2+ channel is uniquely able to signal to the nucleus to regulate gene expression. By unravelling this mechanism, researchers have identified a new approach for developing immunosuppressant drugs.
How the kidney contributes to healthy iron levels and disease
Lakhal-Littleton Group News Publication Research
17 May 2021
A new study from the Lakhal-Littleton Group has addressed a long-standing gap in our understanding of systemic iron homeostasis. It provides the first formal demonstration that the hormone hepcidin controls iron reabsorption in the kidney, in a manner that impacts the body’s iron levels, under normal physiological conditions. It also demonstrates for the first time how this mechanism becomes critically important in the development of iron disorders.
New research to radically alter our understanding of synaptic development
Integrative Neuroscience Molnar Group News Publication Research
14 April 2021
A new study from the Molnár group on the role of regulated synaptic vesicular release in specialised synapse formation has made it to the cover of Cerebral Cortex.
Being "in the zone": how waking activity controls sleep need
Publication Research Vyazovskiy Group News
7 April 2021
A new study from the Vyazovskiy group suggests that how and where we spend our time while awake impacts how much we need to sleep - it does not only depend on how long we are awake.
New target identified to develop treatment for Abdominal Aortic Aneurysm
Publication Research Smart Group News
30 March 2021
A new study from the Smart group has shed light on a key regulatory step in the initiation and progression of Abdominal Aortic Aneurysm by revealing the protective role of a previously little known small protein.
Researcher publishes children's book of the brain
Postdoctoral Publication
4 March 2021
Betina Ip, a Royal Society Dorothy Hodgkin Research Fellow based in NDCN, formerly a postdoctoral research scientist in DPAG, has written a book for children: The Usborne Book of the Brain and How it Works.