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Sugar Promotes Feeding in Flies via the Serine Protease Homolog scarface.
24 September 2018
A balanced diet of macronutrients is critical for animal health. A lack of specific elements can have profound effects on behavior, reproduction, and lifespan. Here, we used Drosophila to understand how the brain responds to carbohydrate deprivation. We found that serine protease homologs (SPHs) are enriched among genes that are transcriptionally regulated in flies deprived of carbohydrates. Stimulation of neurons expressing one of these SPHs, Scarface (Scaf), or overexpression of scaf positively regulates feeding on nutritious sugars, whereas inhibition of these neurons or knockdown of scaf reduces feeding. This modulation of food intake occurs only in sated flies while hunger-induced feeding is unaffected. Furthermore, scaf expression correlates with the presence of sugar in the food. As Scaf and Scaf neurons promote feeding independent of the hunger state, and the levels of scaf are positively regulated by the presence of sugar, we conclude that scaf mediates the hedonic control of feeding.
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Zinc-metalloproteases in insects: ACE and ECE
27 August 2018
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An interesting case of opium tea toxicity
15 October 2018
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The Role of Neuropeptide Y in Cardiovascular Health and Disease.
15 October 2018
Neuropeptide Y (NPY) is an abundant sympathetic co-transmitter, widely found in the central and peripheral nervous systems and with diverse roles in multiple physiological processes. In the cardiovascular system it is found in neurons supplying the vasculature, cardiomyocytes and endocardium, and is involved in physiological processes including vasoconstriction, cardiac remodeling, and angiogenesis. It is increasingly also implicated in cardiovascular disease pathogenesis, including hypertension, atherosclerosis, ischemia/infarction, arrhythmia, and heart failure. This review will focus on the physiological and pathogenic role of NPY in the cardiovascular system. After summarizing the NPY receptors which predominantly mediate cardiovascular actions, along with their signaling pathways, individual disease processes will be considered. A thorough understanding of these roles may allow therapeutic targeting of NPY and its receptors.
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Marianne Fillenz Lecture 2018 - Photos
2 February 2018
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How To Apply
26 September 2014
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Fees & Funding
17 May 2013
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Funding for Public Engagement
13 February 2018
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Opportunities for Public Engagement
13 February 2018
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Resources for Public Engagement
13 February 2018
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Undergraduate Teaching
7 November 2012
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What are the transport functions of the cells that form anatomical follicles in the anterior pituitary?
23 May 2013
Supervisor: Dr Helen Christian & Co-supervisor TBC
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Programming Tumour Progression – Characterising the Role of the Endolysosomal System in Regulating Intracellular and Intercellular Signals
23 May 2013
Supervisor: Dr Deborah Goberdhan, Professor Adrian Harris and Dr Clive Wilson
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Former Chief Technician Awarded Honorary Degree by the Vice-Chancellor
10 October 2018
General Head of Department's News
On 28 September 2018 David O’Connor was admitted to the honorary degree of Master of Arts in a ceremony at the Sheldonian Theatre.
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Oxford Parkinson's Disease Centre Featured on BBC One
17 May 2016
Paul Mayhew-Archer visited the Oxford Parkinson's Disease Centre (OPDC) to find out more about our cutting edge research.
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BBSRC awards cutting-edge biomedical equipment to Oxford
18 December 2013
BBSRC is investing £10m in 20 advanced scientific research instruments.
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Happy retirement to Bob Laynes
15 December 2013
...after a lifetime of exceptional service to the Department!
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How the zebrafish could hold the key to heart disease cure
13 October 2015
Stimulating the heart to repair itself is within scientific touching distance, thanks in large part to the work of Professor Paul Riley and his team in the Department of Physiology, Anatomy and Genetics
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Prof Paul Riley and Prof John Stein elected as Fellow of the Academy of Medical Sciences
11 May 2014
Many congratulations go to both Prof Paul Riley and Prof John Stein on their recent election as Fellows of the Academy of Medical Sciences.
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Dr Thomas Smith: Hypoxia physiology and air travel
18 October 2013
Head of Department Seminar Series
Professor Peter Robbins’ & Dr Keith Dorrington’s group DPAG
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Resources for Public Engagement
13 February 2018
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Research
1 January 2012
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About us
9 October 2012
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History of Diabetes
24 February 2017
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News
17 September 2018
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Goberdhan Group images
29 May 2018
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News
14 January 2013
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Krug Group Images
11 October 2016
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Induction Images
5 January 2018
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Ma Group
19 January 2016
The aim of our work is to determine the cellular mechanisms underlying the benefits of traditional multi-herbal Chinese medicines.
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Threlfell Group
8 April 2014
Exploring mechanisms underlying dopamine neuron vulnerability in Parkinson's disease
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Public Engagement
Public Engagement activities of the FGU
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Physiological Society TV
The Physiological Society YouTube channel.
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New York Times
Female Fruit Flies Like One Mate, or His Brother
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Royal Society
The ‘in-law effect’ – male fruit flies sleep around but females keep it in the family
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Metabolism & Endocrinology
16 January 2018
We use the full range of modern molecular genetic and imaging techniques to study a range of metabolic areas.
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Cardiac Sciences
26 April 2018
We are recognised internationally for our pioneering approaches to systems biology and to computational modelling of the heart.
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Functional Genomics
16 January 2018
We play a leading role in the development of more efficient and cost-effective sequencing technologies.
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Neuroscience
16 January 2018
We host a number of internationally recognised neuroscience groups, with expertise in a wide range of experimental and computational methods.
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Cell Physiology
16 January 2018
We study everything from the structure of ion channels and transporters right up to their role in behaviour and human disease.
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Development & Cell Biology
16 January 2018
We dissect the molecular and cellular mechanisms underlying a range of developmental and reproductive processes.
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Registration for the Cardiac Neuroscience Symposium
22 April 2016
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Oxford BHF CRE PI evening
26 June 2018
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Registration for the Mabel FitzGerald Lecture 2017
21 January 2016
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Register me!
13 March 2015
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Online induction completion
10 August 2018
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Event types
4 November 2017