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An in-depth look into a collaborative DPAG, Chemistry and Oxford Martin School project pioneering a radical new approach in which the brain is repaired with 3D-printed neural tissues.
Samira Lakhal-Littleton
BSc DPhil FESC Samira Lakhal-Littleton - MRC Senior Non-Clinical Research Fellow, Principal Investigator, Professor of Cell Physiology and Tutorial Fellow in Medicine
Interviewees
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Zoltan Molnar
Professor of Developmental Neuroscience
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Francis Szele
Associate Professor of Developmental Biology
Project Collaborators
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Professor of Chemical Biology |
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Oxford Martin Fellow |
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Funder
Related Images
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Human brain progenitor cells differentiate into neurons and astrocytes 13 days after 3D printing. Adapted from Zhou et al., Advanced Materials, June 2020 |
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Layer 6 (green) and layer 5 (red) of the cortex of a Pax 6 mutant mouse cerebral cortex. Adapted from Tuoc et al., Journal of Neuroscience, July 2009 |
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Clonally-related cells labelled in a chick brai. Adapted from García-Moreno et al., Development, April 2014 |
Related Publications
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New insights into the development of the human cerebral cortex.
Journal article
Molnár Z. et al, (2019), J Anat, 235, 432 - 451
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High-Resolution Patterned Cellular Constructs by Droplet-Based 3D Printing.
Journal article
Graham AD. et al, (2017), Sci Rep, 7
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Sip1 downstream Effector ninein controls neocortical axonal growth, ipsilateral branching, and microtubule growth and stability.
Journal article
Srivatsa S. et al, (2015), Neuron, 85, 998 - 1012
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CLoNe is a new method to target single progenitors and study their progeny in mouse and chick.
Journal article
García-Moreno F. et al, (2014), Development, 141, 1589 - 1598
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Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice.
Journal article
Tuoc TC. et al, (2009), J Neurosci, 29, 8335 - 8349
Bayley H. et al, (2020), Advanced Materials
A Tissue-Like Printed Material