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Black In Neuro Week: Dayne Beccano-Kelly on race, academia and research
EDI News Outreach Research
28 July 2020
Black In Neuro Week 2020 is dedicated to celebrating black excellence in neuroscience related fields. Daily social media campaigns highlight key issues and amplify the voices of the Black In Neuro community - #NeuroRacism is the focus of Tuesday 28 July. OPDC Career Development Fellow in Neurobiology Dr Dayne Beccano-Kelly has shared his experience as a black professional working in Parkinson's research in a timely article published in Parkinson's Life.
New evidence against one proposed mechanism of hypoxia in COVID-19
Cell Physiology Publication Research
20 July 2020
DPAG is among the departments receiving funding from the University's research response fund to undertake COVID-19 research. As part of this effort, the Swietach lab has been studying oxygen transport in the blood of COVID-19 patients. The first results of this study are now published in the British Journal of Haematology and could pave the way for new guidelines for treating the virus.
Take part in the first ever British Indian Census!
EDI News Research
13 July 2020
Researchers from DPAG and the Department of Psychiatry, including Dr Nikita Ved, in collaboration with The India League, are calling British Indians to voice their opinions and be a part of a seminal piece of work.
Shaping our understanding of why we sleep
Publication Research Vyazovskiy Group News
1 July 2020
Associate Professor Vladyslav Vyazovskiy has edited a special issue of Current Opinion of Physiology with Professor A. Jennifer Morton from the University of Cambridge. “Physiology of Sleep” compiles the latest developments in sleep research around the complex question of ‘why do we sleep?’
Assumptions on fetal iron development during pregnancy challenged
Lakhal-Littleton Group News Publication Research
18 June 2020
A key hormone in the fetal liver has been found for the first time to play a critical role in determining iron endowment in the newborn baby. Up until now, widely held notions made in comparison to how the adult liver controls iron in the body have led to a common focus on how maternal iron status and function of the placenta determines a baby's iron status. A new study from the Lakhal-Littleton group reveals a more autonomous process takes place within the fetus than previously understood.
URICA trial gives hope for faster diagnosis of hemolysis in the newborn
Cell Physiology Publication Research
12 June 2020
The destruction of red blood cells known as hemolysis in the newborn baby is very dangerous, but existing clinical methods are not sufficient for rapid diagnosis and can lead to delays early-life care. A new Swietach Group paper has identified a biomarker that could significantly speed up the process.
Professor Anant Parekh to be Honorary Guest Speaker at the 108th Indian Science Congress
Awards and Honours Cell Physiology EDI News Research
8 June 2020
Professor Anant Parekh is to deliver the Public Lecture at the prestigious annual conference due to be held in Pune, India, in January 2021.
Dr Oliver Stone starts research group as Sir Henry Dale Fellow
EDI News General Research Stone Group News
1 June 2020
Dr Stone has been awarded a Wellcome Trust Henry Dale Fellowship to lead research investigating how lineage history can impact vascular cell fate and function.
COVID-19 drug trial could lead to enhanced respiratory care for patients
Cell Physiology Research
29 May 2020
Researchers at the University of Oxford led by DPAG's Professor Peter Robbins are working with clinical collaborators from NHS hospitals to carry out a new clinical drug trial aimed at treating COVID-19, funded by LifeArc. It will test a drug that could raise oxygen levels in the blood in COVID-19 patients in order to improve their chances of recovery. Raising oxygen levels is important in COVID-19, because many patients with the disease die when oxygen levels in their arterial blood fall to levels that are too low to support life.
HCQ with antibiotics to treat COVID-19 could be dangerous for the heart
Cardiac Theme Herring Group News Publication Research
26 May 2020
DPAG researchers have collaborated on an international study that demonstrates a detailed mechanistic understanding of how the anti-malaria drug, Hydroxychloroquine, combined with antibiotics, can cause adverse cardiac side-effects in COVID-19 patients. This gives weight to US Federal advice against using this combined treatment.
Nervous system cells defined in unprecedented detail
CNCB Goodwin Group News Publication Research
22 May 2020
The collaborating groups of Professor Stephen Goodwin and Professor Scott Waddell based in The Centre for Neural Circuits and Behaviour (CNCB) are shedding new light on what precisely constitutes a neuronal cell type.
New weight-loss drug brings hope for safer obesity treatment
Domingos Group News Publication Research
13 May 2020
A collaborative research team from the Universities of Oxford and Cambridge co-led by DPAG's Associate Professor Ana Domingos have developed a new weight-loss amphetamine that could potentially avoid the harmful side effects of traditional treatments.
DPAG and RDM researchers set to reveal the role of inflammatory cells in heart repair
Mommersteeg Group News Research Riley Group News
29 April 2020
DPAG's Associate Professor Mathilda Mommersteeg and Professor Paul Riley, in collaboration with Professor Robin Choudhury from the Radcliffe Department of Medicine, will perform single cell analysis of inflammation during heart regeneration with a grant from the Chan Zuckerberg Initiative.
Heart scarring run by Runx1 gene
Mommersteeg Group News Publication Research
27 April 2020
New collaborative research from the Mommersteeg Group and MRC WIMM researchers shows that a protein called Runx1 plays a significant role in the formation of the cardiac scar that forms after the heart is injured, a scar that is known to inhibit heart regeneration. In the zebrafish, a freshwater fish known to be able to fully regenerate its heart after damage, they show that the absence of Runx1 results in enhanced regeneration. This indicates a potential new therapeutic target for heart repair.
New technique could shed light on how blood transports oxygen in disorders such as COVID-19
Cell Physiology Publication Research
23 April 2020
DPAG scientists develop single-cell oxygen saturation imaging to study oxygen handling by red blood cells. New physiological techniques that measure the blood's oxygen saturation are particularly important in light of the current pandemic, as COVID-19 patients present an abnormally low concentration of oxygen in the blood.
Fellowship awarded to Samuel Malone to further research into the sympathetic control of obesity
Awards and Honours EDI News Postdoctoral Research
21 April 2020
Congratulations are in order for Postdoctoral Research Scientist Dr Samuel Malone who was been awarded the Marie Sklodowska Curie Individual Fellowship, funded by the European Commission.
Support Oxford's Response to the COVID-19 Outbreak
General Research
19 March 2020
Funding for Oxford’s COVID-19 research requires unprecedented speed, scope and ambition. Please make a gift.
Communicating the messages of extracellular vesicles to the wider public
Outreach Research Students
2 March 2020
DPAG's Denis Noble has collaborated with Wood Group researchers in the Department of Paediatrics to produce innovative podcast talks on a prominent global platform, the Future Tech Podcast, following the successful DPAG hosted fourth annual Oxosome meeting. Following the release of the final podcast talk in February 2020, today we chart the story leading to these innovative pieces of public engagement.
New human heart model set to boost future cardiac research and therapies
Cardiac Theme Postdoctoral Publication Research
31 January 2020
DPAG's Dr Jakub Tomek and Professor Blanca Rodriguez's Computational Cardiovascular Science Team have developed a new computer model that recreates the electrical activity of the ventricles in a human heart. In doing so, they have uncovered and resolved theoretical inconsistencies that have been present in almost all models of the heart from the last 25 years and created a new human heart model that could enable more basic, translational and clinical research into a range of heart diseases and potentially accelerate the development of new therapies.
New target identified for repairing the heart after heart attack
Publication Research Riley Group News Simoes Group News
30 January 2020
An immune cell is shown for the first time to be involved in creating the scar that repairs the heart after damage. The Riley Group study was funded by the British Heart Foundation and led by BHF CRE Intermediate Transition Research Fellow Dr Filipa Simões.