1 September 2023
A collaborative team of UC Davis and University of Oxford researchers have developed an innovative new software tool – SparkMaster 2 – which will enable automatic analysis of calcium sparks which are known to cause cardiac arrythmias in a variety of disease settings. First and co-corresponding author Dr Jakub Tomek, who is a Sir Henry Wellcome Fellow based in DPAG's Zaccolo group, conducted this research as part of his fellowship year spent at UC Davis.
27 June 2023
New research led by Dr Johanna Michl and Professor Pawel Swietach has solved the longstanding mystery of how cancer cells are able to maintain a relatively alkaline intracellular pH, despite being surrounded by an acidic environment. A raised intracellular pH is required for cancer progression because it allows cancer cells to efficiently proliferate and metastasise. However, until now the exact molecular mechanism underlying this adaptation was unknown.
5 October 2022
A collaborative DPAG-led study studied patients at six and twelve months after COVID-19 infection, finding that prior COVID-19 infection was associated with more uneven inflation of the lungs during normal breathing. There was also an association between hospitalisation with COVID-19 and smaller lung volumes, and admission to the intensive care unit (ICU) was associated with an enlarged respiratory dead space.
Researchers describe how cancer cells can defend themselves from the consequences of certain genetic defects
16 September 2022
Swietach Group scientists have identified a rescue mechanism that allows cancers to overcome the consequences of inactivating mutations in critically important genes.
4 July 2022
The Annual Review Prize Lecture is The Physiological Society's most prestigious lecture.
7 June 2022
The Molecular Flow Sensor Team, with collaborating members principally from DPAG’s Robbins and Talbot groups and the Department of Chemistry, has been named the winner of the Royal Society of Chemistry’s (RSC) Analytical Division Horizon Prize for the development of a new technology for measuring lung function.
5 May 2022
DPAG scientists across four research groups were highlighted at the major annual European Society of Cardiology basic science conference (FCVB 2022). Congratulations are in order for Dr KC Park on receiving the Young Investigator Award and to Dr Elisabetta Gamen on winning the Moderated Poster Prize.
13 April 2022
Research led by Dr Alzbeta Hulikova and Professor Pawel Swietach has, for the first time, described the potential regulation of nuclear acid-base chemistry in neonatal and adult cardiomyocytes, and explained its relevance in the context of heart physiology and pathology.
7 April 2022
A new Klemm Lab-led paper has uncovered a new mechanism involving the endoplasmic reticulum that is critical to the organisation and position of the microtubule (MT) cytoskeleton, which ultimately dictates the shape and function of our body’s cells.
25 March 2022
A new Novo Nordisk project paper has uncovered the role of ACC1 enzyme in the regulation of glucagon secretion for the first time. This raises the prospect of a potential new therapeutic target in the context of type 2 diabetes and metabolic disorders characterised by hyperglycaemia.
21 March 2022
Congratulations are in order to Professor Pawel Swietach, who will represent the Department in strategic decision-making for Oxford Cancer.
11 March 2022
A new paper led by Dr Johanna Michl and Professor Pawel Swietach from DPAG’s Swietach Group has identified a new gene that allows cancer cells to survive in the typically acidic microenvironment of a malignant tumour. They have discovered drugs that inhibit the gene in other medical conditions also selectively kill cancer cells at acidic pH, without damaging healthy tissue. This defines a novel strategy for targeting acidic tumour regions.
13 September 2021
New research from the Swietach Group in collaboration with NHS Blood and Transplant has demonstrated that the process of storing blood in blood banks can negatively impact the function of red blood cells and consequently may reduce the effectiveness of blood transfusions, a treatment commonly used to combat anaemia.
3 September 2021
New research from the Parekh and Zaccolo groups reveals that a prototypical anchoring protein, known to be responsible for regulating several important physiological processes, also orchestrates the formation of two important universal second messengers.
18 May 2021
A new study from the Parekh Group has resolved a long-standing question in our understanding of intracellular Ca2+ signalling, namely how a specific type of Ca2+ channel is uniquely able to signal to the nucleus to regulate gene expression. By unravelling this mechanism, researchers have identified a new approach for developing immunosuppressant drugs.
10 May 2021
Congratulations are in order to Rhodes Scholar Nchimunya Nelisa Tebeka, who has been awarded this year's Diabetes UK Early Career Investigator Award for her DPhil work. This award is awarded for the best basic or clinical science oral abstract presentation at the Diabetes UK Professional Conference.
10 February 2021
A clinical trial has commenced this week to test whether a drug called almitrine can help people who are seriously ill with COVID-19 to recover from the disease.
30 October 2020
Congratulations are in order to Pawel Swietach on his conferral of the title of full Professor. Research in the Swietach Lab is driven by an interest in how biological processes are affected by chemical acidity.
21 October 2020
The Zaccolo Group has identified a new mechanism that regulates mitochondria quality control, a process that is crucial to maintaining healthy cells and preventing disease.
1 September 2020
Collaborative research from a leading US cancer centre and the Swietach Group has found that Low pH in lymph nodes inhibits effector T cells, while still allowing T cell activation.