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New collaborative research from the Mommersteeg Group and MRC WIMM researchers shows that a protein called Runx1 plays a significant role in the formation of the cardiac scar that forms after the heart is injured, a scar that is known to inhibit heart regeneration. In the zebrafish, a freshwater fish known to be able to fully regenerate its heart after damage, they show that the absence of Runx1 results in enhanced regeneration. This indicates a potential new therapeutic target for heart repair.
Samira Lakhal-Littleton
BSc DPhil Samira Lakhal-Littleton - Associate Professor of Cell Physiology and MRC Senior Non-Clinical Research Fellow
Duncan Sparrow
PhD Duncan Sparrow - Associate Professor and BHF Senior Basic Science Research Fellow
Jacinta Kalisch-Smith
PhD Jacinta Kalisch-Smith - Oxford BHF CRE Basic Science Intermediate Transition Fellow