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BHF Fellowship extension for Lisa Heather to further our understanding of metabolic dysfunction in diabetes
Awards and Honours Cardiac Theme EDI News Heather Group News Research
16 June 2023
Congratulations are in order for Associate Professor Lisa Heather, who has been awarded an extension of her British Heart Foundation Intermediate Basic Science Research Fellowship. The extension recognises her successful research on the impact of abnormal metabolism in diabetes on the heart and will prepare her for progression to a Senior Fellowship.
Failing hearts can use different fuels, and prefer fat over sugar
Cardiac Theme Herring Group News Publication Research
31 May 2023
An exciting new collaborative study from RDM and DPAG researchers has found that fat metabolism could be the key to tackling heart failure.
Fellowship to Jose Prius Mengual paves the way to new genetic therapy for epilepsy
Awards and Honours EDI News Postdoctoral Research Vyazovskiy Group News
22 May 2023
Congratulations are in order to Dr Jose Prius Mengual who has been awarded an Emerging Leader Fellowship Award from Epilepsy Research UK and the Nucleic Acid Therapy Accelerator (NATA). With this award, Dr Mengual will develop a new genetic therapy to rebalance protein levels in the neurons affected by epilepsy to prevent seizures.
Fellowship to Hugo Fernandes paves the way to improved treatment options for dementia
Awards and Honours OPDC News Postdoctoral Research Wade-Martins Group News
4 May 2023
Congratulations are in order to Dr Hugo Fernandes who has been awarded a sought after Alzheimer’s Society Dementia Research Leader Fellowship. With this award, Dr Fernandes will reveal the role of dysfunctional lipid metabolism in dementia using innovative self-designed tools and models to identify new therapeutic targets.
Researchers discover why multisensory learning is beneficial for memory
CNCB Postdoctoral Publication Research
26 April 2023
New research published in Nature, led by researchers Dr Zeynep Okray, Dr Pedro Jacob and Professor Scott Waddell at the Centre for Neural Circuits and Behaviour, has discovered a detailed neural circuit mechanism that explains how multisensory learning improves memory performance.
Old and “hangry” monocytes turn from friend to foe under assault
Domingos Group News EDI News Publication Research Students
13 April 2023
Professor Ana Domingos and DPhil student Conan O’Brien review a new study demonstrating that fasting and re-feeding causes monocytes to re-enter the bone marrow and alter the body's response to infection.
Can humans hibernate?
Outreach Research Vyazovskiy Group News
20 March 2023
Illuminating new TEDx Talk from Professor of Sleep Physiology Vladyslav Vyazovskiy
Annie Park to advance our understanding of how the brain encodes reward with new Wellcome Trust Award
Awards and Honours CNCB EDI News Postdoctoral Research
13 March 2023
Congratulations are in order for Postdoctoral Fellow Dr Annie Park who has been awarded a prestigious Wellcome Early-Career Award.
New insights into chemogenetic designer drugs to enhance our study of behaviour
Publication Research Vyazovskiy Group News
10 March 2023
A collaborative team of researchers in DPAG and Pharmacology led by Dr Lukas Krone have uncovered striking new data demonstrating that two widely used designer drugs used to turn populations of neurons on and off in the brain cause unexpected effects on sleep. These results demonstrate a critical need to improve chemogenetic approaches in behavioural studies.
Unlocking the Secrets of cAMP Signalling in the Heart: A Pathway to Targeted Therapeutics
Cardiac Theme Postdoctoral Publication Research
9 March 2023
A new Zaccolo group study has revealed key new insights into the role of cAMP signalling in both healthy and disease settings within the heart. They have identified new cAMP nanodomains in cardiac muscle cells that have far reaching implications for the treatment of heart disease.
Key exosome subtype in cancer progression identified
Publication Research Wilson Group News
8 March 2023
Collaborative work from DPAG and Oncology researchers has revealed a potential new pathway to block the production of a specific group of exosomes made in the cell’s recycling system that can promote the growth of cancerous tumours.
New blood test from DPAG cardiac researchers could save lives of heart attack victims
Cardiac Theme Herring Group News Publication Research
31 January 2023
Researchers from the Herring group have developed a blood test that measures stress hormone levels after heart attacks. The test – costing just £10 – could ensure patients receive timely life-saving treatment.
Mootaz Salman set to target new treatments for stroke
Awards and Honours OPDC News Research Salman Group News Wade-Martins Group News
25 January 2023
The Chief Scientist Office of the Government of Scotland has awarded a collaborative grant of £298,966 to Dr Mootaz Salman to seek new therapeutic avenues to treat stroke.
New BBSRC grant to further our insights into how the cortex controls sleep
Awards and Honours Integrative Neuroscience Molnar Group News Research Vyazovskiy Group News
15 December 2022
Professor of Sleep Physiology Vladyslav Vyazovskiy and Professor of Developmental Neuroscience Zoltán Molnár have been awarded a Project Grant from the Biotechnology and Biological Sciences Research Council (BBSRC) for “Brain mechanisms of sleep: top-down or bottom-up?”
Raised intracellular chloride levels underlie the effects of tiredness in cortex
Publication Research Vyazovskiy Group News
13 December 2022
A new study, co-authored by Professor Vladyslav Vyazovskiy, published in Nature Neuroscience, has revealed that intracellular chloride levels within cortical pyramidal neurons reflect sleep–wake history.
Key cause of type 2 diabetes uncovered
Ashcroft Group News Postdoctoral Publication Research
14 November 2022
Research led by Dr Elizabeth Haythorne and Professor Frances Ashcroft reveals high blood glucose reprograms the metabolism of pancreatic beta-cells in diabetes. They have discovered that glucose metabolites, rather than glucose itself, are key to the progression of type 2 diabetes. Glucose metabolites damage pancreatic beta-cell function, so they are unable to release enough of the hormone insulin. Reducing the rate at which glucose is metabolised, and these glucose metabolites build up, can prevent the effects of hyperglycaemia.
New study shows clinical symptoms for Alzheimer’s can be predicted in preclinical models
OPDC News Publication Research Wade-Martins Group News
10 November 2022
Establishing preclinical models of Alzheimer’s that reflect in-life clinical symptoms of each individual is a critically important goal, yet so far it has not been fully realised. A new collaborative study from the University of Oxford has demonstrated that clinical vulnerability to an abnormally abundant protein in Alzheimer’s brain is in fact reflected in individual patient induced pluripotent stem cell-derived cortical neurons.
Updating the circuit maps of the sympathetic neural network
Domingos Group News Publication Research
3 November 2022
A new review from Professor Ana Domingos’ lab and colleagues offers a fresh modern viewpoint on sympathetic neurons and their relation to immune cells and obesity.
New Pfizer grant paves the way to a better understanding of how body fat is controlled
Awards and Honours Domingos Group News EDI News Research
1 November 2022
Professor Ana Domingos has been awarded a highly competitive independent research grant from Pfizer to discover ‘the role of Sympathetic-associated Perineurial barrier Cells in obesity’.
Collaborative MRC grant paves the way to new therapeutic targets for stress and anxiety disorders
Awards and Honours Integrative Neuroscience Molnar Group News Research
25 October 2022
Dr Armin Lak, Associate Professor Ed Mann and Professor Zoltán Molnár have been awarded a £733K Project Grant from the Medical Research Council on “Orexinergic projections to neocortex: potential role in arousal, stress and anxiety-related disorders”.