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New insights into little understood regulator of blood sugar levels

A new Novo Nordisk project paper has uncovered the role of ACC1 enzyme in the regulation of glucagon secretion for the first time. This raises the prospect of a potential new therapeutic target in the context of type 2 diabetes and metabolic disorders characterised by hyperglycaemia.

Pawel Swietach appointed to Oxford Cancer Oversight Committee

Congratulations are in order to Professor Pawel Swietach, who will represent the Department in strategic decision-making for Oxford Cancer.

Armin Lak set to reveal neural code for learning under uncertainty with ERC Starting Grant

Congratulations are in order for Sir Henry Dale Fellow Dr Armin Lak who has been awarded a Starting Grant from the European Research Council. His funded project will investigate the neural circuits for learning under perceptual uncertainty.

Professor Dame Frances Ashcroft awarded Banting Medal

The 2022 Banting Medal for Scientific Achievement, awarded by the American Diabetes Association, recognises extraordinary leaders in diabetes research, prevention, and treatment.

DPAG raises funds for the humanitarian effort to aid Ukraine

The Department has raised £1,500 at a bake sale led by Lisa Heather and the Cardiac Metabolism Research Group for the Ukraine Humanitarian Appeal.

New gene target identified to prevent tumour growth under acidity

A new paper led by Dr Johanna Michl and Professor Pawel Swietach from DPAG’s Swietach Group has identified a new gene that allows cancer cells to survive in the typically acidic microenvironment of a malignant tumour. They have discovered drugs that inhibit the gene in other medical conditions also selectively kill cancer cells at acidic pH, without damaging healthy tissue. This defines a novel strategy for targeting acidic tumour regions.

New insights into the role of dopamine in reinforcement learning

A new study from Dr Yanfeng Zhang has uncovered the first evidence that dopamine-dependent long-term potentiation is also gated by the pause of striatal cholinergic interneurons and the depolarisation of the striatal spiny projection neurons. This discovery overturns previous ideas that the phasic dopamine release is the only factor gate corticostriatal synaptic plasticity, thus changing our understanding of dopamine functions in reinforcement learning.

Celebrating achievement on International Women's Day

The campaign theme for this year is #BreakTheBias. Celebrate women's achievement. Raise awareness against bias. Take action for equality. This International Women's Day, we celebrate some of the awards, accolades and advances several of DPAG’s women have achieved over the past year, despite the challenges of the pandemic.

Head of Department Statement on the Conflict in Ukraine

IDRM Building reaches practical completion

The IMS-Tetsuya Nakamura Building, which houses the new Institute of Developmental & Regenerative Medicine (IDRM) at Old Road Campus has been completed.

Sarah Teichmann FRS delivers J.S. Haldane Prize Lecture 2022 before unveiling celebrated Haldane portrait

Sarah Teichmann FRS, world leader in computational applications to human health and pioneer of single cell research delivered the second lecture in the series to honour John Scott Haldane, known as the father of oxygen therapy. The lecture was followed by the unveiling of celebrated artist Philip de László's portrait of Haldane by Dr Teichmann and Haldane's great-grandson Terence Mitchison. The Department was delighted to welcome several of J.S. Haldane's descendants to both events.

New insights into how the brain rewires after early sensory loss

A new paper from the Molnár Group has shed light on substantial rewiring of corticothalamic connections that is triggered by early sensory loss during development. The study has identified a new mechanism that significantly rearranges the cortico-thalamo-cortical circuits but has not been considered before in patients with sensory loss for potential therapies.

London Marathon to fund De Val and Vieira Lab research as two of eight handpicked BHF projects

Two projects aimed at tackling heart failure led by Associate Professor Sarah De Val and Dr Joaquim Vieira are to be funded by the 2022 TCS London Marathon with the British Heart Foundation as its Charity of the Year. The BHF’s runners, who are raising £3 million in funding, will include De Val Lab postdoctoral researcher Dr Alice Neal.

Filipa Simões set to advance pro-regeneration heart therapies

Congratulations to Dr Filipa Simões who has been awarded a British Heart Foundation (BHF) Intermediate Basic Science Research Fellowship. She will investigate how immune cells called macrophages facilitate long-lasting heart regeneration in the zebrafish and how this could be harnessed for the human heart.

Hidden lung damage found in Long Covid patients with breathlessness

A major collaborative study, in which DPAG’s Dr James Grist plays a key role, involving teams in the universities of Oxford, Sheffield, Cardiff and Manchester, has identified abnormalities in the lungs of Long Covid patients who are experiencing breathlessness. Researchers are using a novel xenon gas scanning method to locate damaged areas that cannot be detected by routine scans.

Winners of DPAG Image Competition announced

A department-wide image competition has yielded a range of stunning images showcasing the diversity and breadth of DPAG's science. Three prize winners and eight commended pictures are announced.

New book expands the horizons of brain research

A pioneering book from Professor Zoltán Molnár and Yale Professors Tamas Horvath and Joy Hirsch to be released on 1 February 2022 addresses the fundamental relationship between the body, brain and behaviour.

Christoph Treiber awarded ERC Starting Grant to investigate the origins of behavioural diversity

Congratulations are in order for postdoctoral research scientist Dr Christoph Treiber who has been awarded a Starting Grant from the European Research Council. His funded project will investigate the genetic components that may contribute to diversity of brain function and behaviour.

Enriching Engagement grant set to transform public understanding of the human form

A Srinivas Group-led collaborative public engagement project has been awarded more than £188k to bring a multi-disciplinary approach to the concepts of ‘destiny’ and ‘embodiment’ to the local Oxford community.

Eminent neuroscientist Randy Bruno Joins DPAG

This week, Randy Bruno, PhD starts his research group here at DPAG. He joins the Department as Professor of Neuroscience and Tutorial Fellow at St Peter’s College. He was previously an Associate Professor of Neuroscience at Columbia University, Principal Investigator at Columbia’s Mortimer B. Zuckerman Mind Brain Behavior Institute, and a member of the Kavli Institute for Brain Science.

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