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An in-depth look into a collaborative DPAG, Chemistry and Oxford Martin School project pioneering a radical new approach in which the brain is repaired with 3D-printed neural tissues.

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Cerebral blood flow as a mechanistic framework across neurological disease

Journal article

Patel S. et al, (2026), Discover Neuroscience, 21

CreER activation transiently disrupts angiogenesis by reducing proliferation and promoting apoptosis in vascular endothelial cells

Journal article

Ioannou E. et al, (2026), Angiogenesis, 29

Dopamine replacement therapy modulates DDC, prolactin and AOC3 levels in Parkinson’s disease

Journal article

van Hillegondsberg L. et al, (2026), npj Parkinson's Disease

TopoMetry systematically learns and evaluates the latent geometry of single-cell data

Journal article

Sidarta-Oliveira D. et al, (2026), eLife, 13

BODIPY Photocage-Based Injectable Hydrogel for Light-Controlled Nanoparticle Release.

Journal article

Shao B. et al, (2026), Small

Human induced pluripotent stem cell-derived microglia with 1q21.1 deletion and duplication exhibit aberrant inflammatory response

Journal article

Singh T. et al, (2026), Genes and Diseases, 13

Pitch selectivity in ferret auditory cortex

Journal article

Tarka VM. et al, (2026), Current Biology

Cost-effective 3D model reconstruction from the medical images for educational training

Conference paper

Rajendran SS. et al, (2026)

Large Language Models for Generating Interactive Simulations in Anatomy Education

Conference paper

Ershadi-Oskoui G. et al, (2026)

The role of anatomy facilities in the continued professional development of clinicians: An Oxford neurosurgery perspective

Conference paper

Snowdon S. et al, (2026)

Learning shapes neural geometry in the primate prefrontal cortex.

Journal article

Wójcik MJ. et al, (2026), Nat Neurosci

Nucleotide resolution 4-thiouridine sequencing by SNU-Seq and sf4sU-Seq reveals the transcriptional responsiveness of an epigenetically primed human genome.

Journal article

Gerlevik U. et al, (2026), Nucleic Acids Res, 54

Dissecting genotype-specific effects of disease-associated genetic variants.

Journal article

Farrow SL. et al, (2026), iScience, 29

Full Endoscopic versus Microscopic Lumbar Discectomy for Lumbar Disc Herniation: A Meta-analysis of Randomized-controlled Trials.

Journal article

Patel S. et al, (2026), Spine (Phila Pa 1976)

Cell-type-specific cortical feedback coordinates hierarchical credit assignment

Preprint

Greedy W. et al, (2026)

Reactive astrocytes mediate toxicity in iPSC derived dopaminergic neurons.

Journal article

Ibarra-Aizpurua N. et al, (2026), NPJ Parkinsons Dis

Single-cell and spatial transcriptomic analyses of gene therapy-associated retinal inflammation in non-human primates.

Journal article

Sourd C. et al, (2026), Mol Ther Adv, 34

The seminal proteome of a monandrous fly, Drosophila subobscura.

Journal article

Dean R. et al, (2026), Proc Biol Sci, 293

Predicting cage subsidence after lumbar interbody fusion: a meta-analysis of opportunistic bone quality metrics.

Journal article

Patel S. et al, (2026), Spine J

Hypoxia differentially affects coronary vessel formation during heart development.

Journal article

Payne S. et al, (2026), Cardiovasc Res

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Interviewees

Project Collaborators

Hagan Bayley

Professor of Chemical Biology

 HaganBayleyheadshot2.jpg

Linna Zhou

Oxford Martin Fellow

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Funder

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Project Website

3Dprintingforbrainrepairpage.PNG

Read more about the challenge here

Related Images

Image shows Day 13, GFAP Tuj1 vGlut1 at top, image below of brain progenitor cells differentiating into neurons and astrocytes 13 days after 3D printing.

Human brain progenitor cells differentiate into neurons and astrocytes 13 days after 3D printing.

Adapted from Zhou et al., Advanced Materials, June 2020
cortexofmutantmouse.jpg

Layer 6 (green) and layer 5 (red) of the cortex of a Pax 6 mutant mouse cerebral cortex.

Adapted from Tuoc et al., Journal of Neuroscience, July 2009
chickbrain.png

Clonally-related cells labelled in a chick brai.

Adapted from García-Moreno et al., Development, April 2014

Related Publications

New insights into the development of the human cerebral cortex.

Journal article

Molnár Z. et al, (2019), J Anat, 235, 432 - 451

High-Resolution Patterned Cellular Constructs by Droplet-Based 3D Printing.

Journal article

Graham AD. et al, (2017), Sci Rep, 7

Sip1 downstream Effector ninein controls neocortical axonal growth, ipsilateral branching, and microtubule growth and stability.

Journal article

Srivatsa S. et al, (2015), Neuron, 85, 998 - 1012

CLoNe is a new method to target single progenitors and study their progeny in mouse and chick.

Journal article

García-Moreno F. et al, (2014), Development, 141, 1589 - 1598

Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice.

Journal article

Tuoc TC. et al, (2009), J Neurosci, 29, 8335 - 8349

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Lipid‐Bilayer‐Supported 3D Printing of Human Cerebral Cortex Cells Reveals Developmental Interactions

journalarticlegraphiccropped.PNG

Bayley H. et al, (2020), Advanced Materials

greyline.PNG

A Tissue-Like Printed Material

journalarticlegraphiccropped.PNG

Bayley H. et al, (2013), Science, 340, 6128, 48-52
 

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