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The Wade-Martins Group has identified how the dysfunction of a key protein, LRRK2, causes the neurons affected in Parkinson's to lose their ability to effectively clear out cell components that have been damaged. This discovery has enabled the team to find a new way to target and correct this issue, paving the way for a potential new clinical treatment.
New research identifies ways of targeting therapies to the acidic microenvironment of colorectal tumours
General Publication Research Swietach Group News
20 March 2024
Heather Group publishes new paper in Diabetes journal
General Heather Group News Publication Research
13 March 2024
New "Behind the Paper" blog post written for Springer Nature Research Communities
OPDC News Publication Research Wade-Martins Group News
23 February 2024
New Paper on Layer 6b published by Professor Zoltan Molnar and colleagues in Neuron
Molnar Group News Publication Research
15 December 2023
Professor Zoltan Molnar has collaborated with colleagues on a new paper in Neuron.
New research led by Professor Ana Domingos into thermogenesis during fasting wins BBSRC funding
Domingos Group News Research
11 December 2023
Breakthrough Insights: Diffusion-Limited Oxygen Release from Stored Blood Unveiled in New Article
General Publication Research
5 December 2023
In a new article published in Blood, the journal of the American Society of Hematology, researchers from the Department of Physiology, Anatomy, and Genetics (DPAG) and The Nuffield Department of Surgical Sciences (NDS) at the University of Oxford present compelling evidence that challenges established notions about oxygen delivery during organ perfusion.
Researchers characterise the landscape of somatic mutations among acid-base transporters in human cancers
Publication Research
1 December 2023
A new paper lead by DPhil student Bobby White and Professor Pawel Swietach from DPAG’s Swietach Group explores the role that somatic mutations affecting plasma membrane acid-base transporters play in human cancer evolution. The team identify acid-base transporters that are essential to cancer cell survival, and those where somatic mutations are likely to play a driving role in certain cancer types.
Professor Vladyslav Vyazovskiy penguin paper commentary
General Research Vyazovskiy Group News
1 December 2023
Pawel Swietach and KC Park publish paper in Nature Cardiovascular Research
Publication Research
24 November 2023
Working with collaborators from across Oxford (Thomas Milne, Nick Crump, James McCullagh, Roman Fisher, Marjorie Fournier), in Cambridge (Sophie Trefely), and at Great Ormond Street Hospital (Steve Krywawych), Pawel Swietach and KC Park working at DPAG have published a new article, 'Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation', in Nature Cardiovascular Research.
Rui Ponte Costa receives EPSRC New Investigator Award
Awards and Honours Costa Group News Research
15 November 2023
Rui Ponte Costa has received an EPSRC New Investigator award for research exploring Cerebellum-inspired parallel deep learning
The King group has published a new paper in the journal eLife
Publication Research
9 November 2023
Professor Andrew King and members of his research group have just published a new paper ‘Hierarchical temporal prediction captures motion processing along the visual pathway’ in the journal eLife.
Professor Pawel Swietach is author on a new 'Nature Reviews Cancer' article on tumour acidosis
Publication Research
2 November 2023
First digital atlas of human fetal brain development published
Molnar Group News Research
1 November 2023
The first digital atlas showing how the human brain develops in the womb has been published by a global research team led by the University of Oxford.
Flies neglect food and endure shocks to seek a dopamine reward : Waddell Group paper published in Nature
CNCB Head of Department's News Publication Research
25 October 2023
Oxford researchers make first step in engineering human cortical columns for brain repair
Molnar Group News Research
25 October 2023
A collaborative team of DPAG, Chemistry and Oxford Martin School (OMS) researchers have achieved the first step to printing the 6 distinct layers of the cerebral cortex as part of a landmark project seeking to repair brain damage by transplanting replicated ‘pre-organised’ printed neural tissue.
Pioneering new software to analyse intracellular calcium signals
Cell Physiology Postdoctoral Publication Research
1 September 2023
A collaborative team of UC Davis and University of Oxford researchers have developed an innovative new software tool – SparkMaster 2 – which will enable automatic analysis of calcium sparks which are known to cause cardiac arrythmias in a variety of disease settings. First and co-corresponding author Dr Jakub Tomek, who is a Sir Henry Wellcome Fellow based in DPAG's Zaccolo group, conducted this research as part of his fellowship year spent at UC Davis.
International collaboration aims to reveal key insights into Postpartum Depression
Integrative Neuroscience Research
29 August 2023
DPAG is proud to announce a new collaboration, alongside St Anne's College and the Pranaiya and Arthur Magoffin Foundation (PAM Foundation), to research postpartum depression (PPD) and other perinatal mental health illnesses.
Can 3D models of brain-on-chip help in developing new treatments?
Outreach Research Salman Group News Wade-Martins Group News
19 July 2023
Fascinating new TEDx Talk from Departmental Research Lecturer and Leverhulme Fellow Dr Mootaz Salman.
Exploring the importance of early brain development
Integrative Neuroscience Long Read Molnar Group News Research
12 July 2023
Mental health is not written in the stars – but some conditions can be determined even before birth and the origins of some vulnerabilities may lie in the first few months of life, says Professor Zoltán Molnár. Part of the University of Oxford's 'Brain and mental health' campaign.
Researchers discover how cancer cells adapt under acidity
Cell Physiology EDI News Postdoctoral Publication Research
27 June 2023
New research led by Dr Johanna Michl and Professor Pawel Swietach has solved the longstanding mystery of how cancer cells are able to maintain a relatively alkaline intracellular pH, despite being surrounded by an acidic environment. A raised intracellular pH is required for cancer progression because it allows cancer cells to efficiently proliferate and metastasise. However, until now the exact molecular mechanism underlying this adaptation was unknown.