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Milena Cioroch, Research Assistant in the Wade-Martins Lab at the Oxford Parkinson's Disease Centre, is undertaking a Management training course as part of the University of Oxford Apprenticeships scheme. She has been awarded Apprentice of the Month for March 2020 by her training provider Abingdon and Witney College. Here we take a closer look at her work for the department and how she has developed her career through the scheme.
Same genome, different worlds: How a similar brain causes sexually dimorphic behaviours
CNCB Goodwin Group News Publication Research
27 January 2021
A new paper from the Goodwin group based in DPAG's Centre for Neural Circuits and Behaviour has shown how males and females are programmed differently in terms of sex.
New form of gift wrap drives male reproductive success
Publication Research Wilson Group News
26 January 2021
The transfer of complex mixtures of signals and nutrients between individuals is a key step in several biologically important events in our lives, such as breastfeeding and sexual intercourse. However, we know relatively little about the ways in which the molecular gifts involved are packaged to ensure their successful delivery to the recipient.
Just over half of British Indians would take COVID vaccine
EDI News Outreach Postdoctoral Publication Research Riley Group News
21 January 2021
University of Oxford researchers from the Department of Physiology, Anatomy and Genetics (DPAG) and the Department of Psychiatry, in collaboration with The 1928 Institute, have published a major new study on the impact of COVID-19 on the UK’s largest BME population.
Earliest origins of the forming heart identified
Cardiac Theme Postdoctoral Publication Research
8 January 2021
The earliest known progenitor of the outermost layer of the heart has been characterised for the first time and linked to the development of other critical cell types in the developing heart in a new paper from the Srinivas group led by BHF Immediate Fellow Dr Richard Tyser.
A clue to how a memory-enhancing pill might work
CNCB Publication Research
27 November 2020
Hundreds of dietary supplements have been reported to improve cognitive and emotional function in humans, but few have scientific foundation. A new study from the Waddell group provides fresh insight into how dietary Magnesium supplementation can influence memory performance.
New MRI technique could detect early signs of heart failure in cancer patients following chemotherapy
Cardiac Theme Postdoctoral Publication Research
19 November 2020
New research led by Oxford BHF CRE Intermediate Transition Fellow Dr Kerstin Timm shows that a recently developed imaging technique pioneered by the Tyler Group can detect early metabolic changes in the heart caused by a commonly used chemotherapy drug, which is known to increase risk of heart failure in cancer survivors.
Researchers reveal surprising simplicity behind our ability to hear
Postdoctoral Publication Research Students
26 October 2020
A computational modelling study from the King Group demonstrates that the way sounds are transformed from the ear to the brain’s auditory cortex may be simpler than expected. These findings not only highlight the value of computational modelling for determining the principles underlying neural processing, but could also be useful for improving treatments for patients with hearing loss.
New insights into mitochondria quality control could hold the key to treating metabolic disorders
Publication Research Students
21 October 2020
The Zaccolo Group has identified a new mechanism that regulates mitochondria quality control, a process that is crucial to maintaining healthy cells and preventing disease.
‘Junk’ DNA could be rewiring our brains
Postdoctoral Publication Research
16 October 2020
A new study by Waddell Group Neuroscientists at the Centre for Neural Circuits and Behaviour shows that mobile genetic elements that were active in the genomes of our ancestors could be closely linked to important functions in our brain and might help diversify our behaviour, cognition and emotions.
The transient blueprint of the brain
Publication Research
16 October 2020
Transient neurones match the spontaneous and sensory driven activities to shape cortical circuits: a landmark collaborative review published in Science from Professor Zoltán Molnár, Professor Patrick Kanold and Professor Heiko Luhmann.
Sites of early dysfunction in Parkinson's identified
Cragg Group News OPDC News Postdoctoral Publication Research
2 October 2020
A new collaborative study from the Oxford Parkinson’s Disease Centre led by Prof Stephanie Cragg and Dr Bradley Roberts has revealed that GABA transporters on astrocytes, the brain's lesser known yet critically important cells, support dopamine release and are sites of early dysfunction in parkinsonism.
Tiny brain “tweezers” could hold the key to treat Parkinson’s
OPDC News Postdoctoral Publication Research
28 September 2020
A collaborative study led by the OPDC's Dr Nora Bengoa-Vergniory has shown that compounds known as molecular tweezers could become a promising disease modifying therapy for Parkinson’s.
Recharging the battery of the diabetic heart
Cardiac Theme Heather Group News Publication Research
4 September 2020
A new paper from the Heather and Tyler groups has uncovered the mechanism responsible for reduced energy in the hearts of patients with type 2 diabetes and revealed a new therapeutic strategy to reverse the energy deficit.
Acidic niche keeps lymphatic system in check during immune response
Publication Research
1 September 2020
Collaborative research from a leading US cancer centre and the Swietach Group has found that Low pH in lymph nodes inhibits effector T cells, while still allowing T cell activation.
Genetic study points to cells responsible for Parkinson’s
OPDC News Publication Research
25 August 2020
New results from a collaborative Oxford Parkinson’s Disease Centre and Cardiff University study on the cellular origins of Parkinson's could be key to developing new treatments.
How brain networks cooperate to control our sleep
Publication Research Vyazovskiy Group News
13 August 2020
Two new papers from the Vyazovskiy Group and both Oxford University and international collaborators have made important progress in bridging the gap between the local and global levels of sleep regulation.
The ethical cost of doing nothing
Publication Research
7 August 2020
In the wake of concern raised about the ethics and risks of performing genetic interventions in macaque monkeys to study models of human neuropsychiatric conditions, Professor Andrew Parker analyses how decision makers evaluate these situations and highlights the ethical consequences if research is not carried out.
Robin Klemm charts the expanding frontiers of lipid biology
Klemm Group Publication Research
7 August 2020
Associate Professor Robin Klemm has edited a special issue for Seminars in Cell and Developmental Biology. “The molecular cell biology, metabolism and physiological functions of lipid droplets” provides an overview of the most recent developments in the field of lipid droplets, which are important storage organelles at the centre of lipid and energy homeostasis. Prof Klemm joined DPAG in June 2020, bringing with him a new field of research for the department, focusing on the molecular basis of lipid metabolism in professional fat storing cells called adipocytes. His research will impact our basic understanding of the cellular basis of fat metabolism and could lead to innovative new therapies to tackle metabolic disorders such as type II diabetes and obesity.
Researchers discover cell communication mechanism that drives cancer adaptation
Goberdhan Group News Publication Research Wilson Group News
28 July 2020
Collaborative Cancer Research UK-funded studies from DPAG and Oncology researchers have uncovered a new mechanism by which cancer cells adapt to the stresses they encounter as they grow and respond to therapies.
New evidence against one proposed mechanism of hypoxia in COVID-19
Publication Research
20 July 2020
DPAG is among the departments receiving funding from the University's research response fund to undertake COVID-19 research. As part of this effort, the Swietach lab has been studying oxygen transport in the blood of COVID-19 patients. The first results of this study are now published in the British Journal of Haematology and could pave the way for new guidelines for treating the virus.