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Found 170 matches for
Key exosome subtype in cancer progression identified
Publication Research Wilson Group News
8 March 2023
Collaborative work from DPAG and Oncology researchers has revealed a potential new pathway to block the production of a specific group of exosomes made in the cell’s recycling system that can promote the growth of cancerous tumours.
New blood test from DPAG cardiac researchers could save lives of heart attack victims
Cardiac Theme Herring Group News Publication Research
31 January 2023
Researchers from the Herring group have developed a blood test that measures stress hormone levels after heart attacks. The test – costing just £10 – could ensure patients receive timely life-saving treatment.
Raised intracellular chloride levels underlie the effects of tiredness in cortex
Publication Research Vyazovskiy Group News
13 December 2022
A new study, co-authored by Professor Vladyslav Vyazovskiy, published in Nature Neuroscience, has revealed that intracellular chloride levels within cortical pyramidal neurons reflect sleep–wake history.
Key cause of type 2 diabetes uncovered
Ashcroft Group News Postdoctoral Publication Research
14 November 2022
Research led by Dr Elizabeth Haythorne and Professor Frances Ashcroft reveals high blood glucose reprograms the metabolism of pancreatic beta-cells in diabetes. They have discovered that glucose metabolites, rather than glucose itself, are key to the progression of type 2 diabetes. Glucose metabolites damage pancreatic beta-cell function, so they are unable to release enough of the hormone insulin. Reducing the rate at which glucose is metabolised, and these glucose metabolites build up, can prevent the effects of hyperglycaemia.
New study shows clinical symptoms for Alzheimer’s can be predicted in preclinical models
OPDC News Publication Research Wade-Martins Group News
10 November 2022
Establishing preclinical models of Alzheimer’s that reflect in-life clinical symptoms of each individual is a critically important goal, yet so far it has not been fully realised. A new collaborative study from the University of Oxford has demonstrated that clinical vulnerability to an abnormally abundant protein in Alzheimer’s brain is in fact reflected in individual patient induced pluripotent stem cell-derived cortical neurons.
Updating the circuit maps of the sympathetic neural network
Domingos Group News Publication Research
3 November 2022
A new review from Professor Ana Domingos’ lab and colleagues offers a fresh modern viewpoint on sympathetic neurons and their relation to immune cells and obesity.
New computational technique reveals changes to lung function post COVID-19 infection
Cell Physiology Publication Research
5 October 2022
A collaborative DPAG-led study studied patients at six and twelve months after COVID-19 infection, finding that prior COVID-19 infection was associated with more uneven inflation of the lungs during normal breathing. There was also an association between hospitalisation with COVID-19 and smaller lung volumes, and admission to the intensive care unit (ICU) was associated with an enlarged respiratory dead space.
New evidence for how our brains handle surprise
Bruno Group News Integrative Neuroscience Publication Research
30 September 2022
A new study from the Bruno Group is challenging our perceptions of how the different regions of the cerebral cortex function. A group of ‘quiet’ cells in the somatosensory cortex that rarely respond to touch have been found to react mainly to surprising circumstances. The results suggest their function is not necessarily driven by touch, but may indicate an important and previously unidentified role across all the major cortices.
Researchers describe how cancer cells can defend themselves from the consequences of certain genetic defects
Cell Physiology Publication Research
16 September 2022
Swietach Group scientists have identified a rescue mechanism that allows cancers to overcome the consequences of inactivating mutations in critically important genes.
Researchers discover novel form of adaptation in the auditory system
Integrative Neuroscience Publication Research
21 June 2022
DPAG’s auditory neuroscience researchers have found that the auditory system adapts to the changing acoustics of reverberant environments by temporally shifting the inhibitory tuning of cortical neurons to remove reverberation.
The effect of nuclear pH on cardiac gene expression
Cardiac Theme Cell Physiology Postdoctoral Publication Research
13 April 2022
Research led by Dr Alzbeta Hulikova and Professor Pawel Swietach has, for the first time, described the potential regulation of nuclear acid-base chemistry in neonatal and adult cardiomyocytes, and explained its relevance in the context of heart physiology and pathology.
A role of sleep in tinnitus identified for the first time
Integrative Neuroscience Publication Research
8 April 2022
Phantom percepts, such as subjective tinnitus, are driven by fundamental changes in spontaneous brain activity. Sleep is a natural example of major shifts in spontaneous brain activity and perceptual state, suggesting an interaction between sleep and tinnitus that has so far been little considered. In a new collaborative review article from DPAG’s auditory and sleep neuroscientists, tinnitus and sleep research is brought together for the first time, and, in conclusion, they propose a fundamental relationship between natural brain dynamics and the expression and pathogenesis of tinnitus.
An unexpected role for the cell’s largest membrane network
Cell Physiology Klemm Group News Publication Research
7 April 2022
A new Klemm Lab-led paper has uncovered a new mechanism involving the endoplasmic reticulum that is critical to the organisation and position of the microtubule (MT) cytoskeleton, which ultimately dictates the shape and function of our body’s cells.
Little understood brain region linked to how we perceive pain
Integrative Neuroscience Publication Research Vyazovskiy Group News
28 March 2022
A new DPAG-led review paper, published in the journal Brain, has shown that a poorly understood region of the brain called the claustrum may play an important role in how we experience pain.
New insights into little understood regulator of blood sugar levels
Cell Physiology Postdoctoral Publication Research
25 March 2022
A new Novo Nordisk project paper has uncovered the role of ACC1 enzyme in the regulation of glucagon secretion for the first time. This raises the prospect of a potential new therapeutic target in the context of type 2 diabetes and metabolic disorders characterised by hyperglycaemia.
New gene target identified to prevent tumour growth under acidity
Cell Physiology Postdoctoral Publication Research
11 March 2022
A new paper led by Dr Johanna Michl and Professor Pawel Swietach from DPAG’s Swietach Group has identified a new gene that allows cancer cells to survive in the typically acidic microenvironment of a malignant tumour. They have discovered drugs that inhibit the gene in other medical conditions also selectively kill cancer cells at acidic pH, without damaging healthy tissue. This defines a novel strategy for targeting acidic tumour regions.
New insights into the role of dopamine in reinforcement learning
Cragg Group News OPDC News Postdoctoral Publication Research
11 March 2022
A new study from Dr Yanfeng Zhang has uncovered the first evidence that dopamine-dependent long-term potentiation is also gated by the pause of striatal cholinergic interneurons and the depolarisation of the striatal spiny projection neurons. This discovery overturns previous ideas that the phasic dopamine release is the only factor gate corticostriatal synaptic plasticity, thus changing our understanding of dopamine functions in reinforcement learning.
New insights into how the brain rewires after early sensory loss
Integrative Neuroscience Molnar Group News Publication Research
18 February 2022
A new paper from the Molnár Group has shed light on substantial rewiring of corticothalamic connections that is triggered by early sensory loss during development. The study has identified a new mechanism that significantly rearranges the cortico-thalamo-cortical circuits but has not been considered before in patients with sensory loss for potential therapies.
New book expands the horizons of brain research
Integrative Neuroscience Molnar Group News Publication
17 January 2022
A pioneering book from Professor Zoltán Molnár and Yale Professors Tamas Horvath and Joy Hirsch to be released on 1 February 2022 addresses the fundamental relationship between the body, brain and behaviour.
Switch with a spring: a new model for sleep regulation
Publication Research Vyazovskiy Group News
16 December 2021
New collaborative research led by the Vyazovskiy Group has shed new light on the role of the hypothalamus in the transition between sleep and wake states.