Search results
Found 10671 matches for
-
Contrast gain control in mouse auditory cortex.
28 September 2018
The neocortex is thought to employ a number of canonical computations, but little is known about whether these computations rely on shared mechanisms across different neural populations. In recent years, the mouse has emerged as a powerful model organism for the dissection of the circuits and mechanisms underlying various aspects of neural processing, and therefore provides an important avenue for research into putative canonical computations. One such computation is contrast gain control, the systematic adjustment of neural gain in accordance with the contrast of sensory input, which helps to construct neural representations that are robust to the presence of background stimuli. Here, we characterized contrast gain control in mouse auditory cortex. We performed laminar extracellular recordings in the auditory cortex of the anesthetized mouse while varying the contrast of the sensory input. We observed that an increase in stimulus contrast resulted in a compensatory reduction in the gain of neural responses, leading to representations in mouse auditory cortex that are largely contrast invariant. Contrast gain control was present in all cortical layers, but was found to be strongest in deep layers, indicating that intracortical mechanisms may contribute to these gain changes. These results lay a foundation for investigations into the mechanisms underlying contrast adaptation in mouse auditory cortex.
-
3D functional scaffolds for cardiovascular tissue engineering
1 August 2018
© 2018 Elsevier Ltd. All rights reserved. The heart is responsible for providing blood flow to enable perfusion of all tissues and organs with oxygen and nutrients, and is, due to its high oxygen demand and continuous action, particularly susceptible to hypoxia and perfusion deficits. Since the heart is unable to cope with tissue damage and no curative treatment is available, researchers are actively investigating novel therapeutic strategies for cardiac regeneration. Cardiac cell therapy and tissue engineering have attracted considerable attention and clinical trials are ongoing to assess clinical efficacy and accommodate translation to the clinic. In addition, cardiac toxicity as a result of drug therapy is one of the main causes of compound attrition during drug development and post-marketing withdrawal. Moreover, although some cardiotoxicity assays have become standard in drug development, these assays require further improvement as they are prone to false-positive and false-negative outcomes. Stem cell and tissue engineering technologies have been proposed as potential tools for addressing these limitations. In this chapter, we will discuss current developments within these fields and make recommendations for future work.
-
A personalised genetic treatment for DMD
1 August 2018
-
Reagents
30 April 2015
-
Protocols
30 April 2015
Protocols for sgRNA design, RNA preparation, injection and high resolution melt analysis
-
Contact us
30 April 2015
-
The death of Professor Ray Guillery FRS
12 April 2017
-
Public Lectures and School Talks
22 August 2013
-
Cortical neurogenesis
12 September 2013
-
Postdoctoral fellows
12 September 2013
-
Visitors working in Molnár laboratory
12 September 2013
-
Collaborators
3 September 2016
We collaborate with many inspiring researchers, share expertise, resources, reagents, personnel, and, occasionally, conference accommodation... Here is a list of our internal and external collaborators.
-
Zoltan Molnar & partner are first recipients of Newton Advanced Fellowships
26 June 2015
Dr Xiaoqun Wang is one of the first recipient of the prestigious Newton Advanced Fellowships with Professor Zoltan Molnar as his UK partner.
-
New Associate Professors in DPAG
29 July 2014
The Department would like to congratulate Victoria Bajo Lorenzana, Kristine Krug, Damian Tyler and Ji-Long Liu on the award of their title of Associate Professor.
-
Brianna Stubbs Wins Gold at Rowing World Championships
2 September 2016
DPhil Student Brianna Stubbs and her team mates finished top of the medal table at the Senior World Rowing Championships in Rotterdam, The Netherlands.
-
New collaborative research programme on Chinese herbal medicine starts
30 September 2015
A five-year collaborative research programme with Shaanxi Momentum Pharmaceutical Co. Ltd has been signed and a Chinese Herbal medicine research laboratory at DPAG has been granted.
-
Male fruit flies sleep around but females keep it in the family
28 September 2013
Research lead by scientists in DPAG (Stephen Goodwin group) and the Department of Zoology demonstrates that male fruit flies like to have a variety of sexual partners, whereas females prefer to stick with the same mate – or move on to his brothers.
-
Article by leading DPAG scientist in New Statesman
28 September 2013
Dame Kay Davies, Professor of Anatomy and Deputy Chair of the Wellcome Trust, discusses the challenges faced by women who pursue an academic career, in this New Statesman article.
-
DPAG awarded Athena SWAN Bronze
28 September 2013
DPAG's efforts to help promote and advance the careers of women in academia have been recognised in the form of the Athena SWAN bronze award.
-
Sherrington Talks 2016 : Prize Winners
28 June 2016
On 24 June 12 students presented talks about their works to their peers and colleagues. At the close of the event, prizes were presented to the following students:
-
Profs Miesenboeck and Ponting recipients of Wellcome Trust Investigator Awards
3 June 2015
Congratulations to Professor Gero Miesenboeck and Professor Chris Ponting who both received Wellcome Trust Investigator Award in the April 2015 round.
-
Explorations of a Simple Visual Cortex
19 May 2014
-
Neural Control of Sleep and Circadian Rhythms
16 May 2014
-
Conference - Genetic Approaches to Study the Neurobiology of Learning and Memory
27 November 2014
Join us at the Royal Society to discuss the state-of-the-art in linking genes to behaviour.
-
Reaching out to the public
26 September 2014
-
Reaching out to the public
22 February 2016
See Peter Oliver's homepage for Public Engagement activities
-
Public Engagement & Outreach
22 June 2016
-
Links
26 September 2014
-
Noble Group images
10 July 2015
-
OXION
14 April 2015
-
About Us pages
15 August 2018
-
FGU Images
19 November 2014
-
Wilson Group images
21 November 2014
-
Parker Group images
23 June 2015
-
Lakhal-Littleton Group
10 July 2016
Iron Homeostasis- Mechanisms and importance in systems (patho)physiology
-
McMenamin Group
16 September 2013
-
Noble Group
16 September 2013
University of Oxford Innovative Systems Biology Project Sponsored by Tsumura
-
Paterson Group
10 July 2016
Gene Transfer of Nitric Oxide Synthase into Cardiac Nerves Modulates Neurotransmission
-
MRC FGU Public engagement
Find out more about the Heger Group and the Functional Genomics Unit's public engagement here.
-
MRC FGU Public engagement
Find out more about the Nellaker Group and the Functional Genomics Unit's public engagement here.
-
MRC FGU Public engagement
Find out more about the Liu Group and the Functional Genomics Unit's public engagement here.
-
MRC FGU Public engagement
Find out more about the Oliver Group and the Functional Genomics Unit's public engagement here.
-
MRC FGU Public engagement
Find out more about the Ponting Group and the Functional Genomics Unit's public engagement here.
-
MRC FGU Public engagement
Find out more about the Webber Group and the Functional Genomics Unit's public engagement here.