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Inwardly rectifying potassium (Kir) channels regulate the resting membrane potential of the cell and thereby modulate the electrical activity of cardiac and neuronal cells, insulin secretion and epithelial K(+) transport. Considerable progress in understanding the molecular structure of Kir channels and the way in which they are regulated by extracellular and intracellular modulators has been made during the past year.

Original publication

DOI

10.1016/S0955-0674(99)80073-8

Type

Journal article

Journal

Curr Opin Cell Biol

Publication Date

08/1999

Volume

11

Pages

503 - 508

Keywords

Animals, Bartter Syndrome, Humans, Hyperinsulinism, Hypoglycemia, Potassium Channels, Potassium Channels, Inwardly Rectifying, Protein Conformation