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A new paper from the Heather and Tyler groups has uncovered the mechanism responsible for reduced energy in the hearts of patients with type 2 diabetes and revealed a new therapeutic strategy to reverse the energy deficit.

Graphical abstract showing increased energy levels in the heart when mitochondrial deacetylase SIRT3 activator "honokiol" is administered to the diabetic heart, compared to lower levels in the research control group.

Dissecting genotype-specific effects of disease-associated genetic variants

Journal article

Farrow SL. et al, (2026), Iscience, 29

The seminal proteome of a monandrous fly, Drosophila subobscura.

Journal article

Dean R. et al, (2026), Proc Biol Sci, 293

GWAS on short tandem repeats identifies genetic mechanisms in Alzheimer's disease.

Journal article

Gmelin D. et al, (2026), Nat Commun, 17

Nucleophagy removes cytotoxic trapped PARP1.

Journal article

Hoslett G. et al, (2026), Nat Cell Biol

Cerebral blood flow as a mechanistic framework across neurological disease

Journal article

Patel S. et al, (2026), Discover Neuroscience, 21

Hierarchical recurrent temporal prediction as a model of the mammalian dorsal visual pathway.

Journal article

Klavinskis-Whiting S. et al, (2026), PLoS Comput Biol, 22

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