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We have localised a dystrophin-related autosomal gene called DMDL (Duchenne muscular dystrophy-like) to human chromosome 61q24 by in situ hybridisation. Using restriction fragment length polymorphism analysis in two mouse species, we have localised the homologous gene Dmdl in the mouse to chromosome 10 proximal to the Myb oncogene. A neuromuscular disease locus dystrophia muscularis (dy) has previously been assigned to this region of mouse chromosome 10.

Type

Journal article

Journal

Hum Genet

Publication Date

08/1990

Volume

85

Pages

324 - 326

Keywords

Animals, Chromosome Mapping, Chromosomes, Human, Pair 6, Dystrophin, Genetic Linkage, Humans, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred Strains, Muscle Proteins, Muscular Dystrophies, Muscular Dystrophy, Animal