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Maternal alcohol consumption is common prior to pregnancy recognition and in the rat results in altered placental development and fetal growth restriction. To assess the effect of ethanol (EtOH) exposure on the differentiation of trophoblast stem (TS) cells, mouse TS lines were differentiated in vitro for 6 days in 0%, 0.2% or 1% EtOH. This reduced both trophoblast survival and expression of labyrinth and junctional zone trophoblast subtype-specific genes. This suggests that fetal growth restriction and altered placental development associated with maternal alcohol consumption in the periconceptional period could be mediated in part by direct effects on trophoblast development.

Original publication

DOI

10.1016/j.placenta.2016.08.080

Type

Journal article

Journal

Placenta

Publication Date

10/2016

Volume

46

Pages

87 - 91

Keywords

Apoptosis, Differentiation, Ethanol, Placenta, Programming, Animals, Biomarkers, Cell Differentiation, Cell Proliferation, Central Nervous System Depressants, Ethanol, Gene Expression, Mice, Pregnancy Proteins, Trophoblasts