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CRAC channels are a major route for Ca2+ influx in eukaryotic cells. The channels show prominent Ca2+-dependent inactivation through two spatially and temporally distinct mechanisms: fast inactivation, which develops over milliseconds and is triggered by Ca2+ near the mouth of the channel and slow inactivation, which arises over tens of seconds and requires a rise in global cytosolic Ca2+. Slow inactivation is controlled physiologically by Ca2+ uptake into mitochondria through the MCU. Site-directed mutagenesis studies on STIM1 and Orai1 have led to new molecular insight into how fast inactivation occurs. This review describes properties and molecular mechanisms that contribute to these important Ca2+-dependent inhibitory pathways.

Original publication

DOI

10.1016/j.ceca.2016.12.003

Type

Journal article

Journal

Cell Calcium

Publication Date

05/2017

Volume

63

Pages

20 - 23

Keywords

Animals, Calcium, Calcium Release Activated Calcium Channels, Calcium Signaling, Humans, Ion Channel Gating