Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

Serum-stabilized PNA-internalization peptides (Pip) conjugated to PNA complementary to the 705 aberrant beta-globin splice site are able to correct splicing and increase luciferase production in Hela pLuc705 cells with sub microM EC(50) in the absence of a transfection agent. Inhibition of microRNA-122 in liver cells is achieved by treatment with complementary PNA containing just a few attached Lys residues, again without need of a transfection agent.

Original publication

DOI

10.1093/nass/nrn016

Type

Journal article

Journal

Nucleic Acids Symp Ser (Oxf)

Publication Date

2008

Pages

31 - 32

Keywords

Animals, HeLa Cells, Humans, Luciferases, Firefly, Mice, MicroRNAs, Muscular Dystrophy, Duchenne, Peptide Nucleic Acids, RNA Splicing, beta-Globins