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A panel of human monoclonal antibodies reactive with pertussis toxin has been generated by means of Epstein-Barr virus infection. One of these, the 3F11 monoclonal antibody, showed the ability to neutralize in vitro and in vivo the toxic effects of the toxin. Western blot (immunoblot) analysis located the 3F11 epitope on the S3 subunit.

Type

Journal article

Journal

Infect Immun

Publication Date

03/1992

Volume

60

Pages

1258 - 1260

Keywords

Animals, Antibodies, Monoclonal, CHO Cells, Cricetinae, Female, Humans, Immunoglobulin G, Mice, Mice, Inbred BALB C, Pertussis Toxin, Virulence Factors, Bordetella