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The development of the mammalian cerebellum is orchestrated by both cell-autonomous programs and inductive environmental influences. Here, we describe the main processes of cerebellar ontogenesis, highlighting the neurogenic strategies used by developing progenitors, the genetic programs involved in cell fate specification, the progressive changes of structural organization, and some of the better-known abnormalities associated with developmental disorders of the cerebellum.

Original publication

DOI

10.1007/s12311-015-0724-2

Type

Journal article

Journal

Cerebellum

Publication Date

12/2016

Volume

15

Pages

789 - 828

Keywords

Cerebellum, Differentiation, Progenitors, Purkinje cells, Specification