The dominantly inherited cerebellar ataxias are a clinically and genetically heterogeneous group of neurodegenerative disorders. Studies using mouse models as well as recent genetic and transcriptomic human findings point to an important role for TRPC3 signaling in cerebellar ataxia.
Journal article
Cerebellum
12/2017
16
877 - 879
Ataxia, Calcium signaling, Purkinje cell, TRPC3, mGluR1, Animals, Cerebellar Ataxia, Humans, TRPC Cation Channels