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© 2014 The Authors. This paper reviews the development and application of paired muscle preparations, called duplex, for the investigation of mechanisms and consequences of intra-myocardial electro-mechanical heterogeneity. We illustrate the utility of the underlying combined experimental and computational approach for conceptual development and integration of basic science insight with clinically relevant settings, using previously published and new data. Directions for further study are identified.

Original publication

DOI

10.1016/j.pbiomolbio.2014.07.010

Type

Journal article

Journal

Progress in Biophysics and Molecular Biology

Publication Date

01/01/2014

Volume

115

Pages

115 - 128