Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

Uncovering the origins of myocardial cells is important for understanding and treating heart diseases. Cai et al. suggest that Tbx18-expressing epicardium provides a substantial contribution to myocytes in the ventricular septum and the atrial and ventricular walls. Here we show that the T-box transcription factor gene 18 (Tbx18) itself is expressed in the myocardium, showing that their genetic lineage tracing system does not allow conclusions of an epicardial origin of cardiomyocytes in vivo to be drawn.

Original publication

DOI

10.1038/nature07916

Type

Journal article

Journal

Nature

Publication Date

16/04/2009

Volume

458

Pages

E8 - E9

Keywords

Animals, Cell Differentiation, Cell Lineage, Fluorescent Dyes, Gene Expression Regulation, Developmental, Gene Knock-In Techniques, Heart Ventricles, In Situ Hybridization, Integrases, Mice, Myocardium, Myocytes, Cardiac, Pericardium, RNA, Reproducibility of Results, Stem Cells, T-Box Domain Proteins