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Novel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and disease. The concept of compartmentalization is guiding the search for therapies that have the potential to offer greater efficacy and tolerability compared with current treatments.

Original publication

DOI

10.1152/physiol.00040.2013

Type

Journal article

Journal

Physiology (Bethesda)

Publication Date

03/2014

Volume

29

Pages

141 - 149

Keywords

Animals, Cyclic AMP-Dependent Protein Kinases, Humans, Nucleotides, Cyclic, Phosphoric Diester Hydrolases, Second Messenger Systems, Signal Transduction