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In Drosophila, anatomically discrete dopamine neurons that innervate distinct zones of the mushroom body (MB) assign opposing valence to odors during olfactory learning. Subsets of MB neurons have temporally unique roles in memory processing, but valence-related organization has not been demonstrated. We functionally subdivided the αβ neurons, revealing a value-specific role for the ∼160 αβ core (αβc) neurons. Blocking neurotransmission from αβ surface (αβs) neurons revealed a requirement during retrieval of aversive and appetitive memory, whereas blocking αβc only impaired appetitive memory. The αβc were also required to express memory in a differential aversive paradigm demonstrating a role in relative valuation and approach behavior. Strikingly, both reinforcing dopamine neurons and efferent pathways differentially innervate αβc and αβs in the MB lobes. We propose that conditioned approach requires pooling synaptic outputs from across the αβ ensemble but only from the αβs for conditioned aversion.

Original publication

DOI

10.1016/j.neuron.2013.07.045

Type

Journal article

Journal

Neuron

Publication Date

04/09/2013

Volume

79

Pages

945 - 956

Keywords

Animals, Appetitive Behavior, Avoidance Learning, Behavior, Animal, Dopaminergic Neurons, Drosophila, Learning, Memory, Mushroom Bodies, Smell