Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

The intervertebral discs undergo profound changes in structure and composition during development and aging. They also degenerate much earlier than other cartilaginous tissues, and in severe cases may lose function completely. The reasons for this early degeneration are unknown, but external factors, such as mechanical overload on the spine, or smoking, may be involved. However, recent work has revived interest in the importance of genetic and developmental influences on the intervertebral discs.


Journal article


Mol Med Today

Publication Date





329 - 335


Aging, Animals, Back Pain, Embryo, Mammalian, Humans, Intervertebral Disc, Intervertebral Disc Displacement, Spinal Diseases