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Early modelling of cardiac cells (1960-1980) was based on extensions of the Hodgkin-Huxley nerve axon equations with additional channels incorporated, but after 1980 it became clear that processes other than ion channel gating were also critical in generating electrical activity. This article reviews the development of models representing almost all cell types in the heart, many different species, and the software tools that have been created to facilitate the cardiac Physiome Project.

Original publication

DOI

10.1113/jphysiol.2011.224238

Type

Journal article

Journal

J Physiol

Publication Date

01/06/2012

Volume

590

Pages

2613 - 2628

Keywords

Animals, Heart, History, 20th Century, History, 21st Century, Humans, Models, Biological