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Genomewide quantitative-trait locus (QTL) linkage analysis was performed using a continuous measure of relative hand skill (PegQ) in a sample of 195 reading-disabled sibling pairs from the United Kingdom. This was the first genomewide screen for any measure related to handedness. The mean PegQ in the sample was equivalent to that of normative data, and PegQ was not correlated with tests of reading ability (correlations between minus sign0.13 and 0.05). Relative hand skill could therefore be considered normal within the sample. A QTL on chromosome 2p11.2-12 yielded strong evidence for linkage to PegQ (empirical P=.00007), and another suggestive QTL on 17p11-q23 was also identified (empirical P=.002). The 2p11.2-12 locus was further analyzed in an independent sample of 143 reading-disabled sibling pairs, and this analysis yielded an empirical P=.13. Relative hand skill therefore is probably a complex multifactorial phenotype with a heterogeneous background, but nevertheless is amenable to QTL-based gene-mapping approaches.

Original publication

DOI

10.1086/339249

Type

Journal article

Journal

Am J Hum Genet

Publication Date

03/2002

Volume

70

Pages

800 - 805

Keywords

Chromosome Mapping, Chromosomes, Human, Pair 17, Chromosomes, Human, Pair 2, Dyslexia, Functional Laterality, Genetic Heterogeneity, Genetic Testing, Genome, Human, Great Britain, Hand, Heterozygote, Humans, Matched-Pair Analysis, Nuclear Family, Phenotype, Quantitative Trait, Heritable, Reading