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One widespread and conserved Ca(2+) entry pathway in eukaryotic cells is the store-operated CRAC channel and Ca(2+) entry through these channels activates a disparate array of cellular responses. Under physiological conditions, mitochondria are important regulators of CRAC channel gating. Through these actions, mitochondria help control a range of spatially and temporally distinct CRAC channel-driven responses including enzyme activation, secretion, intercellular communication through paracrine signals and gene expression.

Original publication

DOI

10.1016/j.ceca.2012.02.003

Type

Journal article

Journal

Cell Calcium

Publication Date

07/2012

Volume

52

Pages

52 - 56

Keywords

Calcium, Calcium Channels, Calcium Signaling, Enzyme Activation, Humans, MAP Kinase Kinase Kinases, Membrane Proteins, Mitochondria, Neoplasm Proteins