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The classical type of KATP channel is an octameric (4:4) complex of two structurally unrelated subunits, Kir6.2 and SUR. The former serves as an ATP-inhibitable pore, while SUR is a regulatory subunit endowing sensitivity to sulphonylurea and K+ channel opener drugs, and the potentiatory action of MgADP. Both subunits are required to form a functional channel.

Type

Journal article

Journal

Curr Opin Neurobiol

Publication Date

06/1998

Volume

8

Pages

316 - 320

Keywords

ATP-Binding Cassette Transporters, Adenosine Triphosphate, Ion Channel Gating, Potassium Channels, Potassium Channels, Inwardly Rectifying, Receptors, Drug, Signal Transduction, Sulfonylurea Receptors