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Akinesia is the most disabling symptom of Parkinson's disease. The neural mechanisms underlying it probably involve the descending projections of the basal ganglia to the brain stem as it improves after a pallidotomy or subthalamic nucleotomy but not after a thalamotomy. We describe the effects of lesioning the pedunculopontine nucleus in the normal primate in generating an akinetic syndrome. The possible clinical implications of this study are discussed.


Journal article


Br J Neurosurg

Publication Date





245 - 249


1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Basal Ganglia, Brain Mapping, Brain Stem, Dominance, Cerebral, Dyskinesia, Drug-Induced, Female, Macaca mulatta, Neural Pathways, Parkinsonian Disorders