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Long-lasting memories are most efficiently formed by multiple training sessions separated by appropriately timed intervals. A recent study revealed that expression of a transgene encoding an inhibitor of protein phosphatase 1 (PP1) in the forebrain enhanced memory formed during sub-optimal training. Thus, PP1 apparently constrains memory formation in the mouse. Furthermore, the report proposes that PP1 promotes forgetting.

Original publication

DOI

10.1016/S0166-2236(03)00029-8

Type

Journal article

Journal

Trends Neurosci

Publication Date

03/2003

Volume

26

Pages

117 - 119

Keywords

Animals, Learning, Memory, Mice, Mice, Transgenic, Phosphoprotein Phosphatases, Prosencephalon, Protein Phosphatase 1, Signal Transduction