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We have investigated the effects of agents interfering with the cAMP pathway on the rate of miniature IPSCs in cerebellar slices. Noradrenaline and group II glutamate metabotropic receptor agonists respectively enhance and reduce the rate of miniature IPSCs, presumably because they respectively increase and decrease the presynaptic concentration of cAMP.

Type

Journal article

Journal

J Physiol Paris

Publication Date

1996

Volume

90

Pages

327 - 328

Keywords

Adenine, Adenylyl Cyclase Inhibitors, Animals, Cerebellum, Cyclic AMP, Cyclic AMP-Dependent Protein Kinases, Enzyme Inhibitors, In Vitro Techniques, Membrane Potentials, Rats, Receptors, Metabotropic Glutamate, Staurosporine, Synapses, Thionucleotides, gamma-Aminobutyric Acid