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The purpose of this study was to ascertain if effects of halothane and sevoflurane (0.18-1.45 MAC) on the magnitude of the rise in intracellular calcium ([Ca(2+)]i with approximately 90s hypoxia (measured using indo-1 dye) in rat pup carotid body type I glomus cells. paralleled their known effects on the human hypoxic ventilatory response, where halothane is more depressive. We also assessed these agents' effect on [Ca(2+)]i response to 100 mM K(+). Halothane depressed the [Ca(2+])i transient in hypoxia more than sevoflurane (p = 0.036). Both agents also depressed the [Ca(2+)]i response to K+ - halothane more than sevoflurane (p = 0.004). These actions reflect their known influence on human hypoxic ventilatory response, consistent with the notion that the cellular process underlies the whole-body effect. The responses to K(+), which depolarises the cell membrane, indicates that in addition to a putative effect on K(+) channels, voltage-activated Ca(2+) channels may also be involved in the anaesthetic effect.

Original publication

DOI

10.1007/978-1-4419-5692-7_40

Type

Journal article

Journal

Adv Exp Med Biol

Publication Date

2010

Volume

669

Pages

201 - 204

Keywords

Anesthetics, Animals, Calcium, Carotid Body, Dose-Response Relationship, Drug, Halothane, Hypoxia, Intracellular Space, Methyl Ethers, Rats, Rats, Sprague-Dawley