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RNA is not only a messenger operating between DNA and protein. Transcription of essentially the entire eukaryotic genome generates a myriad of non-protein-coding RNA species that show complex overlapping patterns of expression and regulation. Although long noncoding RNAs (lncRNAs) are among the least well-understood of these transcript species, they cannot all be dismissed as merely transcriptional "noise." Here, we review the evolution of lncRNAs and their roles in transcriptional regulation, epigenetic gene regulation, and disease.

Original publication

DOI

10.1016/j.cell.2009.02.006

Type

Journal article

Journal

Cell

Publication Date

20/02/2009

Volume

136

Pages

629 - 641

Keywords

Animals, Evolution, Molecular, Gene Expression Regulation, Humans, RNA, Untranslated