Is it time for in silico simulation of drug cardiac side effects?

Mirams GR.; Noble D.

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Is it time for in silico simulation of drug cardiac side effects?

Mirams GR., Noble D.

Cardiac simulation is used to integrate information on drug action to predict side effects on the whole heart. Could simulation begin to replace animal models?

Original publication

DOI

10.1111/j.1749-6632.2011.06324.x

Type

Journal article

Journal

Ann N Y Acad Sci

Publication Date

12/2011

Volume

1245

Pages

44 - 47

Keywords

Animals, Drug Evaluation, Preclinical, ERG1 Potassium Channel, Ether-A-Go-Go Potassium Channels, Heart, Humans, Ion Channels, Models, Cardiovascular, Torsades de Pointes