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In recent years, the development of new technologies based on the green fluorescent protein and FRET (fluorescence resonance energy transfer) has introduced a new perspective in the study of cAMP signalling. Real-time imaging of fluorescent biosensors is making it possible to visualize cAMP dynamics directly as they happen in intact, living cells, providing important and original insights for our understanding of the spatiotemporal organization of the cAMP/PKA (protein kinase A) signalling pathway.

Original publication

DOI

10.1042/BST20051323

Type

Journal article

Journal

Biochem Soc Trans

Publication Date

12/2005

Volume

33

Pages

1323 - 1326

Keywords

Animals, Biosensing Techniques, Cell Compartmentation, Cyclic AMP, Cyclic AMP-Dependent Protein Kinases, Fluorescence Resonance Energy Transfer, Green Fluorescent Proteins, Microscopy, Fluorescence, Myocytes, Cardiac, Second Messenger Systems