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Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here we summarise our non-human primate investigations of relevance to our surgical targeting of the PPN and relate the primate research to initial clinical experience of PPN DBS. © Springer-Verlag 2010.

Original publication

DOI

10.1007/s00702-011-0631-8

Type

Journal article

Journal

Journal of Neural Transmission

Publication Date

01/10/2011

Volume

118

Pages

1453 - 1460