Targeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities.
Machado ND., Heather LC., Harris AL., Higgins GS.
In light of the disappointing termination of clinical trials with potent complex I inhibitors, such as IACS-010759, justification for oxidative phosphorylation inhibitors and mitochondrial targeting strategies has been called into question. Consideration of these agents’ potency, tissue selectivity and toxicity demonstrate what lessons can be learned from this failure and where new opportunities lie.