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To study the modulated electrical potential specifically related to the electrode-brain interface (EBI) in deep brain stimulation (DBS) under physiological condition, we quantitatively identified the physiologically modulated electrode potentials by decomposing the local field potentials (LFPs) recorded from 11 patients (18 electrodes in four different brain regions) who underwent DBS, and correlated them with simultaneously recorded physiological signals of blood pressure (BP) and respiration. Results showed that electrode potentials were modulated by BP and respiration and could be detected as a specific component of the compound LFP signals with a mean (+/-S.D.) amplitude of 6.9+/-1.7 microV. The detection rate and amplitude of the modulated electrode potentials were independent from brain regions and neurological disorders. The current approach can be used to study the changes in properties of the EBI under physiological condition and to investigate the effects of the EBI on the 'crossing' current of either the neural signals to be recorded or the electrical pulses for neurostimulation.

Original publication

DOI

10.1016/j.neulet.2006.04.015

Type

Journal article

Journal

Neurosci Lett

Publication Date

24/07/2006

Volume

402

Pages

238 - 243

Keywords

Blood Pressure, Brain, Deep Brain Stimulation, Electrodes, Implanted, Electrophysiology, Humans, Movement Disorders, Pain, Pain Management, Respiration