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Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here we summarise our non-human primate investigations of relevance to our surgical targeting of the PPN and relate the primate research to initial clinical experience of PPN DBS.

Original publication

DOI

10.1007/s00702-011-0631-8

Type

Journal article

Journal

J Neural Transm (Vienna)

Publication Date

10/2011

Volume

118

Pages

1453 - 1460

Keywords

Animals, Bicuculline, Biophysics, Convulsants, Deep Brain Stimulation, Disease Models, Animal, GABA-A Receptor Agonists, History, 20th Century, Humans, Macaca, Male, Muscimol, Parkinson Disease, Pedunculopontine Tegmental Nucleus