Latent TGF-β hydrogels for cartilage tissue engineering.
Place ES., Nair R., Chia HN., Szulgit G., Lim E-H., Stevens MM.
A biomimetic delivery strategy for transforming growth factor beta (TGF-β) is described, in which TGF-β is presented in a latent form (the small latent complex, SLC), which is inactive until modified by the actions of the cells. In this work, SLC is tethered to a hyaluronic acid hydrogel scaffold to enhance in vitro chondrogenesis.