The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and--when barrier integrity is impaired--in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.
Nat Rev Neurosci
169 - 182
Animals, Biological Transport, Blood-Brain Barrier, Brain, Cerebrovascular Circulation, Humans, Nervous System Diseases, Neuroprotective Agents, Neurosciences, Translational Medical Research