Engaging neuroscience to advance translational research in brain barrier biology.

Neuwelt EA., Bauer B., Fahlke C., Fricker G., Iadecola C., Janigro D., Leybaert L., Molnár Z., O'Donnell ME., Povlishock JT., Saunders NR., Sharp F., Stanimirovic D., Watts RJ., Drewes LR.

The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and--when barrier integrity is impaired--in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.

DOI

10.1038/nrn2995

Type

Journal article

Journal

Nat Rev Neurosci

Publication Date

03/2011

Volume

12

Pages

169 - 182

Keywords

Animals, Biological Transport, Blood-Brain Barrier, Brain, Cerebrovascular Circulation, Humans, Nervous System Diseases, Neuroprotective Agents, Neurosciences, Translational Medical Research

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