Revisiting dopamine-acetylcholine imbalance in Parkinson's disease: Glutamate co-transmission as an exciting partner in crime.

Zhang Y-F., Cragg SJ.

Striatal dopamine and acetylcholine are thought to be imbalanced in Parkinson's disease. In this issue of Neuron, Cai et al. report that restoration of nigral glutamate co-transmission, acting on dorsolateral striatal cholinergic interneuron mGluR1s, can rescue motor dysfunction in a mouse model of Parkinson's.

DOI

10.1016/j.neuron.2021.03.018

Type

Journal article

Journal

Neuron

Publication Date

07/04/2021

Volume

109

Pages

1070 - 1071

Keywords

Acetylcholine, Animals, Cholinergic Agents, Corpus Striatum, Crime, Dopamine, Glutamic Acid, Interneurons, Mice, Motor Disorders, Parkinson Disease

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