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Vero cells infected with herpes simplex virus in the presence of actinomycin or cycloheximide, or with u.v.-inactivated virus, suffered a rapid loss of functional mRNA as determined by translation in vitro. It is suggested that a virion-associated factor causes a structural change in the mRNA of the host cell.

Original publication

DOI

10.1099/0022-1317-65-7-1225

Type

Journal article

Journal

J Gen Virol

Publication Date

07/1984

Volume

65 ( Pt 7)

Pages

1225 - 1228

Keywords

Animals, Cells, Cultured, Gene Expression Regulation, Herpes Simplex, Polyribosomes, Protein Biosynthesis, RNA, Messenger, Simplexvirus